1. 毕业设计（论文）的内容和要求

本课题涉及合成具有亚细胞靶向和过氧化氢响应的BODIPY衍生物，借助季铵盐的的线粒体靶向性，通过二茂铁官能团催化过氧化氢分解形成高活性的羟基自由基，提升细胞氧化应激。

通过光热作用和氧化应激的协同作用，破坏线粒体的膜结构及其DNA，促使其失能，达到杀死癌细胞并消除肿瘤，实现肿瘤治疗的目的。

2. 参考文献

1. Tang Z, Liu Y, He M, et al. Chemodynamic Therapy: Tumour Microenvironment‐Mediated Fenton and Fenton‐like Reactions[J]. Angewandte Chemie International Edition, 2019, 58(4): 946-956. 2. Shen Z, Liu T, Li Y, et al. Fenton-Reaction-Acceleratable Magnetic Nanoparticles for Ferroptosis Therapy of Orthotopic Brain Tumors[J]. ACS nano, 2018, 12(11): 11355-11365. 3. Feng L, Xie R, Wang C, et al. Magnetic Targeting, Tumor Microenvironment-Responsive Intelligent Nanocatalysts for Enhanced Tumor Ablation[J]. ACS nano, 2018, 12(11): 11000-11012. 4. Liu Y, Zhen W, Jin L, et al. All-in-one theranostic nanoagent with enhanced reactive oxygen species generation and modulating tumor microenvironment ability for effective tumor eradication[J]. ACS nano, 2018, 12(5): 4886-4893. 5. Ranji-Burachaloo H, Gurr P A, Dunstan D E, et al. Cancer Treatment through Nanoparticle-Facilitated Fenton Reaction[J]. ACS nano, 2018, 12(12): 11819-11837. 6. Kwon B, Han E, Yang W, et al. Nano-Fenton reactors as a new class of oxidative stress amplifying anticancer therapeutic agents[J]. ACS applied materials interfaces, 2016, 8(9): 5887-5897. 7. Ding Y, Wan J, Zhang Z, et al. Localized Fe (II)-induced cytotoxic reactive oxygen species generating nanosystem for enhanced anticancer therapy[J]. ACS applied materials interfaces, 2018, 10(5): 4439-4449. 8. Cheng H, Zhu J Y, Li S Y, et al. An O2 self‐sufficient biomimetic nanoplatform for highly specific and efficient photodynamic therapy[J]. Advanced Functional Materials, 2016, 26(43): 7847-7860. 9. Zhang K, Meng X, Cao Y, et al. Metal#8211;Organic Framework Nanoshuttle for Synergistic Photodynamic and Low‐Temperature Photothermal Therapy[J]. Advanced Functional Materials, 2018, 28(42): 1804634。

10. Zhang C, Bu W, Ni D, et al. Synthesis of iron nanometallic glasses and their application in cancer therapy by a localized Fenton reaction[J]. Angewandte Chemie International Edition, 2016, 55(6): 2101-2106. 11. Lin L S, Song J, Song L, et al. Simultaneous Fenton‐like Ion Delivery and Glutathione Depletion by MnO2‐Based Nanoagent to Enhance Chemodynamic Therapy[J]. Angewandte Chemie, 2018, 130(18): 4996-5000. 12. Liu Y, Zhen W, Wang Y, et al. One-Dimensional Fe2 P Acts as a Fenton Agent in Response to NIR II Light and Ultrasound for Deep Tumor Synergetic Theranostics[J]. Angewandte Chemie (International ed. in English), 2019, 58(8): 2407. 13. Wang Y, Yin W, Ke W, et al. Multifunctional polymeric micelles with amplified fenton reaction for tumor ablation[J]. Biomacromolecules, 2018, 19(6): 1990-1998. 14. Ma B, Wang S, Liu F, et al. Self-Assembled Copper#8211;Amino Acid Nanoparticles for in Situ Glutathione ”AND” H2O2 Sequentially Triggered Chemodynamic Therapy[J]. Journal of the American Chemical Society, 2018, 141(2): 849-857. 15. Yu Z, Zhou P, Pan W, et al. A biomimetic nanoreactor for synergistic chemiexcited photodynamic therapy and starvation therapy against tumor metastasis[J]. Nature communications, 2018, 9(1): 5044.

3. 毕业设计（论文）进程安排

3月1日-3月15日 准备阶段 对相关因为文献进行阅读和翻译，撰写实验计划和开题报告 3月16日-4月底 材料合成阶段 合成系列中间体和BODIPY衍生物，确认分子结构 4月底-5月中旬 材料性质表征阶段 纳米材料的制备和表征、测试材料的光学性质和光热性能、研究过氧化氢响应性质 5月中旬-6月初 论文撰写和答辩