1. 研究目的与意义（文献综述）

1.1 anatomy of skin

the skin is the largest organ in the humanbody [1]. humanskin consists of three layers: the epidermis, dermis, and the hypodermis. theepidermis is the outermost layer of skin. keratinocytes and melanocytes areprominent cell types of the epidermis. the basement membrane physicallyseparates the epidermis from the underlying dermis. progenitor cells arelocated on the basement membrane and undergo continuous self-renewal anddifferentiation into keratinocytes. the dermis, beneath the epidermis, containstough connective tissue, hair follicles, and sebaceous and sweat glands.cellular components of the dermis include the fibroblasts. the deepersubcutaneous tissue (hypodermis) is made of fat and connective tissue [2][3].

2. 研究的基本内容与方案

1. 制备海藻酸钠薄膜模拟致密表皮结构，抑制细菌感染，防止水分蒸发。

2. 通过部分氧化海藻酸钠制备多醛基海藻酸钠抑制其离子交换反应，使其降解速率适当提高且可控，易于从体内排出，并提高其反应活性和压缩模量以及动态剪切模量，还可以通过偶联生物活性物质对其本体进行修饰以提高其与细胞的相互作用。

3. 鉴别氧化海藻酸钠中的醛基，并测定氧化海藻酸钠中醛基的浓度和氧化度及其相对分子质量。

4. 制备氧化海藻酸钠/丝素片层多孔材料模拟真皮疏松结构，诱导细胞长入，促进组织生长，防止伤口回缩。

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   3. 研究计划与安排

   时间	阶段研究计划
   2018.10.1-2018.10.31	制备氧化海藻酸钠/丝素双层支架材料
   2018.11.1-2018.11.30	对氧化海藻酸钠/丝素双层支架材料进行理化性能和结构性能表征
   2108.12.1-2018.12.27	对氧化海藻酸钠/丝素双层支架材料进行体外降解性能和体外生物相容性表征

   4. 参考文献（12篇以上）

   1. dahiya r s,valle m. robotic tactile sensing: technologies and system[m]. springer scienceamp; business media, 2012.

   2. chen, m., przyborowski, m., berthiaume, f.,2009. stem cells for skin tissue engineering and wound healing. crit. rev.biomed. eng. 37 (45), 399421.

   3. akter f, ibanezj, bulstrode n. skin engineering[m]//tissue engineering made easy. 2016: 17-27.

   4. vitello, paul. "dr. john f. burke,dies at 89; created synthetic skin". retrieved 2018-07-30.

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