1. 毕业设计（论文）的内容和要求

光动力治疗的三个重要因素是光敏剂、照射光、氧气。

为了提高治疗效果，科研工作者们一直致力于优化要素，光敏剂的设计与研究更是成为研究焦点。

目前常用加入重原子的方式来提高光敏剂的自旋轨道耦合以提高单线态氧产率，但加入重原子会导致暗毒性增加。

2. 参考文献

1. KILIORAN J, ALLEN L, GALLAGHER J F et al. Synthesis of BF2 chelates of tetraarylazadipyrromethenes and evidence for their photodynamic therapeutic behavior. Chem Commun. 2002(17): 1862-1863. 2. MCDONNELL S O, O#8217;SHEA D F. Near-infrared sensing properties of dimethylamino-substituted BF2-azadipyrromethenes. Org. Lett. 2006.8(16):3943-3946. 3. GE Y, O#8217;SHEA D F, Azadipyrromethenes from traditional dye chemistry to leading edge applications. Chem. Soc. Rev. 2016, 45(14) :3846-3864. 4. S L Luo, E L Zhang, Y P Su, et al. A review of NIR Dyes in Cancer Targeting and Imaging. Biomaterials, 2011, (32):7127 - 7138. 5. Rogers M A T.156.2: 4-Diarylpyrroles. Part Ⅰ. Synthesis of 2: 4-diarylpyrroles and 2#8217;2#8217;:4: 4#8217;-tetra-arylazadipyrromethines. J. Am. Chem. Soc. 1943: 590-596. 6. Tugba Ozdemir, Jose Luis Bila, Fazli Sozmen, Leyla T. Yildirim, and Engin U. Akkaya. Orthogonal Bodipy Trimers as Photosensitizers for Photodynamic Action. Org. Lett. 2016, 18, 4821#8722;4823. 7. X L Cai, J Liu, W H Liew, et al. Organic Molecules with Propeller Structures for Efficient Photoacoustic Imaging and Photothermal Ablation of Cancer cells. Mater Chem Front, 2017, (8):1556 - 1562. 8. H J Zhu, P H Cheng, P Chen, et al. Recent Progress in the Development of Near-Infrared Organic Photothermal and Photodynamic Nanotherapeutics. Biomaterials Sci, 2018, (6):746 - 765. 9. L Cheng, K Yang, Q Chen, Organic Stealth Nanoparticles for Highly Effective in Vivo Near-Infrared Photothermal Therapy of Cancer. Acs Nano, 2012, (6):5605 -5613 10. J Qi, Y Fang, R T K Kwok, et al. Highly Stable Organic Small Molecular Nanoparticles as an Advanced and Biocompatible Phototheranostic Agent of Tumor in Living Mice. Acs Nano, 2017, (11):7177 - 7188. 11. D L Sheng, T Z Liu, L M Deng, et al. Perfluorooctyl Bromide Indocyanine Green Co-loaded Nanoliposomes for Enhanced Multimodal Imaging-Guided Phototherapy. Biomaterial, 2018, (165):1 - 13. 12. X J Song, Q Chen, Z Liu. Recent Advances in the Development of Organic Photothermal Nano-Agents[J]. Nano Research，2015，(8):340 -354. 13. A L Antaris, H Chen, K Cheng, et al. A Small-Molecule Dye for NIR-II Imaging. Nature Mater, 2016, (15):235 - 243. 14. Y Sun, C R Qu, H Chen, et al. Novel Benzo-Bis(1,2,5-thiadiazole) Fluorophores for in Vivo NIR-II Imaging of Cancer. Chem Sci，2016，(16)：6203 ~ 6207. 15. B H Li, L F Lu, M Y Zhao, et al. Deep-Tissue High-Resolution Dynamic Bioimaging. Angew Chem Int Ed, 2018, (57):1 - 6.

3. 毕业设计（论文）进程安排

每周六天，每天8-10小时。

1、第1-4周：文献阅读，了解相关领域的研究动态，课题背景；学习实验室安全知识。

2、第5-8周：学习实验室安全知识；进入实验室学习。