1. 毕业设计（论文）的内容和要求

1. 熟悉基本的实验操作，理解实验的基本内容； 2. 能做做到流利阅读文献，掌握文献内容； 3. 熟练运用各种信息平台查阅相关信息； 4. 了解当下有机化学方向中硫叶立德与氮杂三元环的反应的内容，了解它的背景以及意义； 5.熟悉并掌握 硫叶立德与氮杂三元环的反应的机理。

2. 参考文献

[1]. Palacios Francisco.; Retana Ana Mar#305;′a Ochoa de.; Gil Jose′ Ignacio, et al. Synthesis of Pyrazine-phosphonates and -Phosphine Oxides from 2H-Azirines or Oximes. Org. Lett., 2002, 4 (14), 2045 - 2048; [2]. Time′n #197;sa Sjo#168;holm.； Somfai Peter .; Investigation of Lewis Acid-Catalyzed Asymmetric Aza-Diels-Alder Reactions of 2H-Azirines. J. Org. Chem., 2003, 68, 9958 - 9963； [3]. Alves M. Jose′.; Dura#732;es M. Miguel.; Fortes A. Gil. Cycloaddition of methyl 2-(2,6-dichorophenyl)-2H-azirine-3carboxylate to electron-rich 2-azadienes.Tetrahedron Letters., 2003, 44, 5079 - 5082； [4]. Hong Bor-Cherng.; Gupta Arun Kumar.; Wu Ming-Fun,et al. Formal [6 3] cycloaddition of fulvenes with 2H-azirine: afacile a pproach to the [2]pyrindines system. Tetrahedron Letters., 2003, 45, 1663#8211;1666; [5]. Zheng Yunhui.; Yang Chao.; Zhang-Negrerie Daisy, et al. One-pot synthesis of isoxazoles from enaminones: an application of Fe(II) as the catalyst for ring expansion of 2H-azirine intermediates. Tetrahedron Letters., 2013, 54, 6157 - 6160; [6]. Rostovskii Nikolai V.; Novikov Mikhail S. ,. Khlebnikov Alexander F, et al.Cu(II)-catalyzed domino reaction of 2H-azirines with diazotetramic and diazotetronic acids. Synthesis of 2-substituted 2H-1,2,3-triazoles#8224;. Org. Biomol. Chem., 2013, 11, 5535-5545; [7]. Ding Haixin.; Hong Sanguo.; Zhang Ning. Rhodium(II)-catalyzed transannulation of 1-sulfonyl-1,2,3-triazoles with 2H-azirines: a new method to dihydropyrazines. Tetrahedron Letters., 2015, 56, 507 - 510; [8]. Zeng Ting-Ting.; Xuan Jun.; Wei Ding, et al. [3 2] Cycloaddition/Oxidative Aromatization Sequence via Photoredox Catalysis: One-Pot Synthesis of Oxazoles from 2H#8209;Azirines and Aldehydes. Org. Lett., 2015, 17, 4070 - 4073; [9]. Galenko Ekaterina E.; Galenko Alexey V.; Khlebnikov Alexander F, et al. Domino transformation of isoxazoles to 2,4-dicarbonylpyrroles under Fe/Ni relay catalysis. RSC Adv., 2015, 5, 18172 - 18176; [10]. Gallo Rafael D. C.; Ahmad Anees.; Metzker Gustavo, et al. α,α-Alkylation-Halogenation and Dihalogenation of Sulfoxonium Ylides. A Direct Preparation of Geminal Difunctionalized Ketones. Chem. Eur. J., 2017, 23, 16980 #8211; 16984; [11]. Phelps Alicia M.; Chan Vincent S.; Napolitano Jose#769; G, et al. Ligand-Controlled Synthesis of Azoles via Ir-Catalyzed Reactions of Sulfoxonium Ylides with 2#8209;Amino Heterocycles. J. Org. Chem., 2016, 81, 4158 - 4169; [12]. Lou Mei-Mei.; Wang Han.; Li Song, er al. The Epoxidation of Carbonyl Compounds with a Benzyne-Triggered Sulfur Ylide. J. Org. Chem., 2016, 81, 5915 #8722; 5921; [13]. Wang Qiang.; Li Tian-Ren.; Lu Liang-Qiu, et al. Catalytic Asymmetric [4 1] Annulation of Sulfur Ylides with Copper#8722;Allenylidene Intermediates. J. Am. Chem. Soc., 2016, 138, 8360 - 8363; [14]. Aggarwal Varinder K.; Jean-Luc Vasse. Asymmetric Sulfur Ylide Mediated Aziridination: Application in the Synthesis of the Side Chain of Taxol. Org. Lett., 2003, 5 (21), 3987 -3990; [15]. Takayam Chikako.; Takeuch Keiko.; Shin-ichi Ohkoshi, et al. Reactions of Alkylidene-Bridged Cobaltadithiolene Complexes with Lewis Bases. Formation of M-S Sulfur Ylide Structure. Organometallics. 1999, 18, 2843-2850;

3. 毕业设计（论文）进程安排

2017.12.1-2018.3.1 查阅资料，完成开题报告和任务书 2018.3.2-2018.3.10 确定方案，学习实验过程和操作 2018.3.11-2018.4.30 独立实验，合成产品并进行结构表征 2018.5.1-2018.5.30 数据整理，书写论文，制作PPT 2018.5.30- 修改论文并完成答辩