1. 毕业设计（论文）的内容和要求

1.掌握文献查阅的一般方法，学会使用化学料相关的数据库进行查阅相关文献。

2.阅读与课题相关的外文及中文文献，了解国内外的研究动态，撰写课题报告。

3.根据所查文献内容，确定实验内容与方案。

2. 参考文献

[1] Aruri, H.; Singh, U.; Kumar, M.; Sharma, S.; Aithagani, S. K.; K. Gupta, V.; Mignani, S.; A.Vishwakarma, R.; Singh, P. P. Metal-free Cross-Dehydrogenative Coupling of HN-azoles with α-C(sp3)-H Amides via C-H Activation and Its Mechanistic and Application Studies. J. Org. Chem. 2017, 82, 1000#8722;1012 [2] Das, R.; Kapur, M. Palladium-Catalyzed, ortho-Selective C-H Halogenation of Benzyl Nitriles, Aryl Weinreb Amides, and Anilides. J. Org. Chem. 2017, 82, 1114-1126 [3] Ye, L.; Lo, K.; Gu, Q. S.; Yang, D. Pd-Catalyzed Intramolecular Aminoalkylation of Unactivated Alkenes: Access to Diverse N-Heterocycles. Org. Lett. 2017, 19, 308#8722;311 [4] Yuan, C. C.; Tu, G. L.; Zhao, Y. S.; Rhodium(III)-Catalyzed Selective Monoarylation of β or γ C(sp3)#8722;H Bonds Assisted by a Trimethylpyrazole Group. Org. Lett. 2017, 19, 356#8722;359 [5] Yang, X. L.; Shan, G.; Yang, Z.; Huang, G. Y.; Dong, G. Q.; Sheng, C. Q.; Rao, Y.; One-pot synthesis of quaternary carbon centered cyclobutanes via Pd(II)-catalyzed cascade C(sp3)-H activations. Chem. Commun. 2017, 53, 1534--1537 [6] Chen, G.; Zhuang, Z.; Li, G.; Tyler, G. S.; Hsiao, Y.; Candice, L. J.; Yu, J. Q. Ligand-Enabled β-C-H Arylation of α-Amino Acids Without Installing Exogenous Directing Groups Angew. Chem. Int. Ed. 2017, 56, 1506-1509. [7] Hu, X. Q.; Chen, J. R.; Xiao, W. J. Controllable Remote C-H Bond Functionalization by Visible-Light Photocatalysis. Angew. Chem. Int. Ed. 2017, 56, 1960-1962. [8] N. Wenzel, M.; K. Owens, P.; T. W. Bray, J.; M. Lynam, J.; M. Aguiar, P.; Reed, C.; D. Lee, J.; F. Hamilton, J.; C. Whitwood, A.; J. S. Fairlamb, I. Redox Couple Involving NOx in Aerobic Pd-Catalyzed Oxidation of sp3-C#8722;H Bonds: Direct Evidence for Pd-NO3#8722;/NO2#8722; Interactions Involved in Oxidation and Reductive Elimination. J. Am. Chem. Soc. 2017, 139, 1177-1190 [9] Lopez, E.; Borge, J.; A. Lopez, L. Gold-Catalyzed Intermolecular Formal Insertion of Aryldiazo Esters into Cp-H Bonds of Iron and Ruthenium Metallocenes. Chem. Eur. J. 2017, 23, 1-8 [10] Yada, A.; Liao, W. Q.; Sato, Y.; Murakami, M. Buttressing Salicylaldehydes:A Multipurpose Directing Group for C(sp3)-H Bond Activation. Angew .Chem. Int. Ed. 2017, 56, 1073-1076 [11] Tan, Y.; Yuan, W.; Gong, L.; Meggers, E. Aerobic Asymmetric Dehydrogenative Cross-Coupling between Two Csp3-H Groups Catalyzed by a Chiral-at-Metal Rhodium Complex. Angew. Chem. Int. Ed. 2015, 54, 13045-13048. [12] Wang, R.; Sun, X. Y.; Zhang, B. S.; Sun, X. Y.; Su, D. S. Hybrid Nanocarbon as a Catalyst for Direct Dehydrogenation of Propane: Formation of an Active and Selective Core-Shell sp2/sp3 Nanocomposite Structure. Chem. Eur. J. 2014, 20, 6324-6331. [13] Wang, H.; Tang, G. D.; Li, X. W. Rhodium(III)-Catalyzed Amidation of Unactivated C(sp3)-H Bonds. Angew. Chem. Int. Ed. 2015, 54, 13049-13052. [14] Wu, X. S.; Zhao, Y.; Ge, H. B. Copper-Promoted Site-Selective Acyloxylation of Unactivated C(sp3)-H Bonds Chem. Asian. J. 2014, 9, 2736-2739. [15] Petronilho, A.; A.Woods, J.; Mueller-Bunz, H.; Bernhard, S.; Albrecht, M. Iridium Complexes Containing Mesoionic C Donors: Selective C(sp3)-H versus C(sp2)-H Bond Activation, Reactivity Towards Acids and Bases,and Catalytic Oxidation of Silanes and Water. Chem. Eur. J. 2014, 20, 15775-15784.

3. 毕业设计（论文）进程安排

2016.12.15 进入实验室，交待相关事宜，安排实验任务； 2017.2-2017.3 查阅文献，准备开题报告； 2017.3.3 提交开题报告。

2017.3-2017.4 合成试验所需原料； 2017.4-2017.6 选择相应的催化剂催化反应进行，筛选条件，优化反应条件； 2017.5-2017.6 实验数据整理与分析。

2017.6-2017.6 撰写论文, 论文答辩。