1. 毕业设计（论文）的内容和要求

1、毕业论文内容 28-高芸苔素内酯是一种新型绿色环保植物生长调节剂，被称为第六类激素。

其生物活性兼具其它五类激素的部分功能特性，对于促进各种植物的生长有非常重要的作用，其生物活性远远超过现有五大激素，并且适用于大部分植物的大部分时期。

天然植物中提取得到的芸苔素内酯系列化合物的含量极少，且提取产物纯度不高，难以满足研究和应用需求。

2. 参考文献

[1] 曹立冬, 吴进龙, 李友顺, 陈铁春, 黄啟良. 芸苔素内酯类化合物的合成与分析方法研究进展[J]. 农业科学与管理, 2016, 37(9): 12-19. [2] Victor Mukherjee, D. Vijayalaksmi, Jagadeesh Gulipalli, R. Premalatha, Shamim A. Sufi, Athithan Velan, Kotteazeth Srikumar. A Plant Oxysterol, 28-Homobrassinolide Binds HMGCoA Reductase Catalytic Cleft: Stereoselective Avidity Affects Enzyme Function[J]. Molecular Biology Reports, 2016, 43(10): 1049-1058. [3] Trevor C. McMorris, Prakash A. Patil, Rodrigo G. Chavez, Michael E. Baker, Steven D. Clouse. Synthesis and Biological Activity of 28-Homobrassinolide and Analogues[J]. Phytochemistry, 1994, 36(3): 585-589. [4] Suguru Takatsuto, Masahito Muramatsu. Synthesis Of 2,3-Diacetate Derivatives of (22S,23S)- and (22R,23R)-28-Homobrassinolides[J]. Agricultural and Biological Chemistry, 1988, 52(11): 2943-2945. [5] Weishan Zhou, Biao Jiang, Xinfu Pan. Stereoselective Synthesis of Tee Brassinolide Side Chain: Novel Syntheses of Brassinolide and Related Cofwounds[J]. Tetrahedron, 1990, 46(9): 3173-3188. [6] Lydia R. Galagovsky, Eduardo G.Gros, Javier A. Ram#305;#769;rez. Synthesis and Bioactivity of Natural and C-3 Fluorinated Biosynthetic Precursors of 28-Homobrassinolide[J]. Phytochemistry, 2001, 58(6): 973-980. [7] Suguru Takatsuto, Naoto Yazawa, Nobuo Ikekawa, Tadashi Morishita, Hiroshi Abe. Synthesis of (24R)-28-Homobrassinolide Analogues and Structure-activity Relationships of Brassinosteroids in the Rice-lamina Inclination Test[J]. Phytochemistry, 1983, 22(6): 1393-1397. [8] Archna P. Massey, Vandana S. Pore, Braja G. Hazra. New Route for the Synthesis of (22S,23S)-28-Homobrassinolide[J]. Synthesis, 2003, 3, 426-430. [9] R. Premalatha, K. Srikumar, D. Vijayalaksmi, G. N. Kumar, P. Mathur. 28-Homobrassinolide: A Novel Oxysterol Transactivating LXR Gene Expression[J]. Molecular Biology Reports, 2014, 41(11): 7447-7461. [10] R. Premalatha, Rajamanickam Jubendradass, S. Judith Amala Rani, K. Srikumar, Premendu Prakash Mathur. A phytooxysterol, 28-homobrassinolide modulates rat testicular steroidogenesis in normal and diabetic rats[J]. Reproductive sciences, 2013, 20(5): 589-596.

3. 毕业设计（论文）进程安排

起讫日期 设计（论文）各阶段工作内容2019.1-2019.2 完成文献检索和开题报告 2019.3-2019.4 第一步磺酰化反应的工艺研究 2019.5-2019.6 第二步闭环反应的工艺研究 2019.6 数据整理、论文写作和答辩