1. 毕业设计（论文）的内容和要求

1．文献查阅 掌握文献查阅的一般方法，学会使用计算机在中国期刊网维普数据库超 掌握文献查阅的一般方法，学会使用计算机在中国期刊网维普数据库超 掌握文献查阅的一般方法，学会使用计算机在中国期刊网维普数据库超 掌握文献查阅的一般方法，学会使用计算机在中国期刊网维普数据库超 星数字图书馆， elsevier 、ncbi 电子期刊， springer link 全文电子期刊 ，pubmed 等检索资源上查阅关于 遗传转化体系构建 的相关文献。

2．文献阅读及综述 阅读与课题相关的外文及中献，了解国内研究动态撰写综述。

3．明确实验任务，拟定方案 根据所查阅文献的内容，确定实验及方案拟科学可行研究计划。

2. 参考文献

[1] Ma M , Huang Y , Chen H , et al. Bi2S3-embedded mesoporous silica nanoparticles for efficient drug delivery and interstitial radiotherapy sensitization[J]. Biomaterials, 2015, 37:447-455. [2] Persson M , Kjaer A . Urokinase-type plasminogen activator receptor (uPAR) as a promising new imaging target: potential clinical applications[J]. Clinical Physiology and Functional Imaging, 2013, 33(5):329-337. [3] Braun G B , Sugahara K N , Yu O M , et al. Urokinase-controlled tumor penetrating peptide.[J]. Journal of Controlled Release, 2016, 232:188-195. [4] Fujiwara K , Kuwahara Y , Sumida Y , et al. Synthesis of Ag nanoparticles encapsulated in hollow silica spheres for efficient and selective removal of low-concentrated sulfur compounds[J]. Journal of Materials Chemistry A, 2017, 5(48). [5] Qasim M , Singh B R , Naqvi A H , et al. Silver nanoparticles embedded mesoporous SiO2 nanosphere: An effective anticandidal agent against Candida albicans 077[J]. Nanotechnology, 2015, 26. [6]. Prilepskii AY, Fakhardo AF, Drozdov AS, Vinogradov VV, Dudanov IP, Shtil AA, et al. Urokinase-Conjugated Magnetite Nanoparticles as a Promising Drug Delivery System for Targeted Thrombolysis: Synthesis and Preclinical Evaluation[J]. ACS applied materials interfaces. 2018,10(43):36764-75. [7] Huang H , Lovell J F . Advanced Functional Nanomaterials for Theranostics[J]. Advanced Functional Materials, 2016, 27(2). [8] Cicha I. Thrombosis: Novel nanomedical concepts of diagnosis and treatment. World Journal of Cardiology. 2015;7:434-41 [9] Huang S-S, Wei S-C, Chang H-T, Lin H-J, Huang C-C. Gold nanoparticles modified with self-assembled hybrid monolayer of triblock aptamers as a photoreversible anticoagulant. Journal of Controlled Release. 2016;221:9-17 [10] Kim Y T, Lobatto M E, Kawahara T, et al. Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis[J]. Proc Natl Acad Sci U S A, 2014, 111(3):1078-1083. [11] Lobatto M E, Calcagno C, Millon A, et al. Atherosclerotic Plaque Targeting Mechanism of Long-Circulating Nanoparticles Established by Multimodal Imaging[J]. Acs Nano, 2015, 9(2):1837-47. [12] Jin H J, Zhang H, Zhang B G, et al. Urokinase-coated chitosan nanoparticles for thrombolytic therapy: preparation and pharmacodynamics in vivo[J]. Journal of Thrombosis Thrombolysis, 2013, 36(4):458-468.

3. 毕业设计（论文）进程安排

起讫日期 设计（论文）各阶段工作内容 2019.1.2-2019.1.19 文献查询和资料阅读 2019.1.19-2019.1.23 研究方案制定和开题报告撰写 2019.1.24-2019.3.10 实验内容的准备 2019.3.11-2019.5.10 实验内容处理 2019.5.10-2019.5.15 实验结果分析 2019.5.16-2019.6.1 毕业论文书写