1. 毕业设计（论文）的内容和要求

1.文献查阅从查阅文献着手，通过使用计算机在中国期刊网，维普数据库，超星数字图书馆，美国化学学会（acs）数据库，ca，sci等检索资源上查阅雷诺嗪的制备工艺等相关文献。

熟悉了文献查找的方法和步骤，对以前学者所做的研究进行了了解，并确定自己的研究方向，研究范围。

明确了本次论文所要解决的问题，以及解决途径和拟采用的方法。

2. 参考文献

[1] Li J, Yuan H, Bai Y, et al. Dapoxetine for premature ejaculation: an updated meta-analysis of randomized controlled trials [J]. Clin Ther, 2014, 36(12): 2003-2014. [2] Razzak M. Sexual dysfunction: dapoxetine shown to be safe for premature ejaculation [J]. Nat Rev Urol, 2013, 10(10): 558-558. [3] Kashid AM, Waghmare SA, Thombare SD, et al. Development and validation of a HPLC analytical assay method for dapoxetine tablets:a medicine for premature ejaculation [J]. J Chem Pharm Res, 2014, 6(7): 1613-1618. [4] Pratik M，Ujjwal S，Seth AK. Development and validation of a RP-HPLC method for the determination of dapoxetine hydrochloride in pharmaceutical dosage form [J]. Int J Pharm Sci Rev Res, 2011, 6(2): 76-78. [5] Giri AD, Bhusari VK, Dhaneshwar SR. Validated HPLC method for simultaneous quantitation of Tadalafi l and Dapoxetine hydrochloride in bulk drug and formulation [J]. Int J Pharm Pharm Sci, 2012, 4(2):654-658. [6] Siddartha B, Babu IS. Analytical method development and validation for simultaneous estimation of sildenafi l and dapoxetine in bulk pharmaceutical dosage form by RP-HPLC method [J]. Der Pharm Chem, 2014, 6(4):393-399. [7] Patil RB, Deshmukh TA, Patil VR. Stability indicating HPLC method for dapoxetine HCl in bulk and in formulation [J]. Int J Pharml Sci, 2014, 6(5):687-690. [8] Liew K, Peh KK. Stability indicating HPLC-UV method for determination of dapoxetine HCl in pharmaceutical product [J]. Acta Poloniae Pharmaceutica, 2014, 71(3):393-400. [9] Rohith T, Ananda S. Development and validation of high performance liquid chromatography method for the determination of process related impurities in dapoxetine hydrochloride [J]. Int J Res Pharm Chem, 2013, 3(1，Cop):74-82. [10] 冯光玲，冯爱国，丁文娟，等 . 一种达泊西汀中有关物质的高效液相色谱法测定方法：中国，CN201310619658.6 [P]. 2014-07-16.

3. 毕业设计（论文）进程安排

起讫日期 设计（论文）各阶段工作内容： 2018.1.15～2018.3.1 确定课题，查阅文献。

2018.3.2～2018.3.19 研究设计试验方案，熟悉试验细节。

2018.3.20～2018.4.30 建立相关化合物的定性和定量分析方法，并建立实验方法，进行实验。