1. 毕业设计（论文）的内容和要求

1．文献查阅 掌握文献查阅的一般方法，学会使用计算机在中国期刊网、维普数据库、超星数字图书馆、美国化学学会（acs）数据库、英国皇家化学学会（rcs）数据库、elseiver、isi chemistry server、ei、ca 等检索资源上查阅有关原料合成的相关文献。

2．文献阅读及综述 阅读与课题相关的外文及中文文献，了解国内外的研究动态，撰写文献综述。

3．明确实验任务，拟定实验方案 根据所查阅文献的内容，确定实验内容及方案，拟定科学可行的研究计划。

2. 参考文献

[1] Mizoroki T, Mori K, Ozaki, A. Arylation of olefin with aryl iodide catalyzed by palladium[J]. Bulletin of the Chemical Society of Japan, 1971, 44: 581. [2] Heck R. F, Nolley J P. Palladium-Catalyzed Vinylic Hydrogen Substitution Reactions with Aryl, Benzyl, and Styryl Halides[J]. Journal of Organic Chemistry, 1972, 37: 2320-2322. [3] Cabri W, Candiani I. Recent Developments and New Perspectives in the Heck Reaction[J]. Accounts of Chemical Research, 1995, 28:2-7. [4] Beletskaya I P, Cheprakov A. V. The Heck Reaction as a Sharpening Stone of Palladium Catalysis[J]. Chemical Reviews, 2000, 100:3009-3066. [5] Dounay A B, Overman L E. The Asymmetric Intramolecular Heck Reaction in Natural Product Total Synthesis[J]. Chemical Reviews, 2003, 103, 2945-2964. [6] Karimi B, Behzadnia H, Elhamifar D, Akhavan P. F, Esfahani F. K, Zamani A. Transition-Metal-Catalyzed Oxidative Heck Reactions[J]. Synthesis, 2010, 2010: 1399-1427. [7] Ruan J, Xiao J. From a-Arylation of Olefns to Acylation with Aldehydes: A Journey in Regiocontrol of the Heck Reaction[J]. Accounts of Chemical Research, 2011, 44: 614-626. [8] Pandey G, Tiwari K N, Puranik V G. Use of Enantiomerically Pure 7-Azabicyclo[2.2.1]heptan-2-ol as a Chiral Template for the Synthesis of Aminocyclitols[J]. Organic Letters, 2008, 10: 3611-3614． [9] Noshi M N, EI-awa A, Torres E, et al．Conversion of Cyclic Vinyl Sulfones to Transposed Vinyl Phosphonates[J]. Journal of the American Chemical Society, 2007, 129: 11242-11247． [10] Desrosiers J N, Charette A B. Catalytic enantioselective reduction of β,β-disubstituted vinyl phenyl sulfones by using bisphosphine monoxide ligands[J]. Angewandte Chemie, International Edition, 2007, 46: 5955－5957． [11] Ettari R, Nizi E, Francesco M E D. Development of Peptidomimetics with a Vinyl Sulfone Warhead as Irreversible Falcipain-2 Inhibitors[J]. Journal of Medicinal Chemistry, 2008, 51: 988-996． [12] Wang G, Mahesh U, Chen G Y J, et al. Solid-Phase Synthesis of Peptide Vinyl Sulfones as Potential Inhibitors and Activity-Based Probes of Cysteine Proteases[J]. Org.Lett, 2003, 5: 737-740． [13] Ni L, Zheng X S, Somers P K, et al. Bioorganic Medicinal Chemistry Letters, 2003, 13: 745-748． [14] Palmer J T, Rasnick D, Klaus J L, et al．Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors[J]. Journal of Medicinal Chemistry, 1995, 38: 3193-3196． [15] Simpkins N S. The chemistry of vinyl sulfones[J].Tetrahedron, 1990, 46: 6951-6984．

3. 毕业设计（论文）进程安排

2018.1.12~2018.3.19 查阅文献，做出研究方案，完成外文翻译和开题报告，开始实验 2018.3.20~2018.3.24 总结前一阶段工作，完成中期自检和中期汇报，确定下一阶段目标 2018.3.25~2018.4.30 扩展课题研究范围，改进实验方案，对 数据整理分析，撰写论文 2018.5.1~2018.6.7 完善毕业论文 2018.6.7~2018.6.14 准备毕业答辩