1. 毕业设计（论文）的内容和要求

关联T4噬菌体溶菌酶突变的各种热力学数据，开发一种能够关联、预测酶的突变效应的简单的网路模型。

2. 参考文献

1. Akhterov, M.V., et al., Observing lysozyme's closing and opening motions by high-resolution single-molecule enzymology. ACS Chem Biol, 2015. 10(6): p. 1495-501. 2. Baase, W.A., et al., Lessons from the lysozyme of phage T4. Protein Sci, 2010. 19(4): p. 631-41. 3. Choi, Y., et al., Single-molecule lysozyme dynamics monitored by an electronic circuit. Science, 2012. 335(6066): p. 319-24. 4. Held, J. and S. van Smaalen, The active site of hen egg-white lysozyme: flexibility and chemical bonding. Acta Crystallogr D Biol Crystallogr, 2014. 70(Pt 4): p. 1136-46. 5. Kazmirski, S.L. and V. Daggett, Non-native interactions in protein folding intermediates: molecular dynamics simulations of hen lysozyme. J Mol Biol, 1998. 284(3): p. 793-806. 6. Somboonpatarakun, C., et al., Role of His101 in the Protein Folding/Unfolding of a Goose-Type Lysozyme from Ostrich (Struthio camelus) Egg White. Protein J, 2016. 35(6): p. 416-423. 7. Xu, J., et al., The response of T4 lysozyme to large-to-small substitutions within the core and its relation to the hydrophobic effect. Protein Sci, 1998. 7(1): p. 158-77. 8. Zhang, X.J., W.A. Baase, and B.W. Matthews, Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability. Protein Sci, 1992. 1(6): p. 761-76.

3. 毕业设计（论文）进程安排

2月中旬-3月中旬：文献检索、数据准备、模型准备 3月中旬--5月中旬：数据模拟,统计分析，建模。

5月中旬--六月上旬：论文写作