1. 毕业设计（论文）的内容和要求

水凝胶由于具有良好的生物相容性，可降解性，无毒性，高药物负载能力，释放速率可制和载药稳定性等优点，因此水凝胶非常适用于生物医学应用。

聚n-异丙基丙烯酰胺(pnipam)是众多水凝胶中，最广泛应用于药物释放的聚合物。

pnipam水凝胶在较低的临界溶解温度(lcst)下表现出非线性体积相变的特点，该温度非常接近于人体的自然温度。

2. 参考文献

[1] R. Langer, D.A. Tirrell, Designing materials for biology and medicine, Nature, 428 (2004) 487#8211;492. [2] M. Verhulsel, M. Vignes, S. Descroix, L. Malaquin, D.M. Vignjevic, J.-L. Viovy, A review of microfabrication and hydrogel engineering for micro-organs on chips, Biomaterials, 35 (2014) 1816#8211;1832. [3] R.A. Sheldon, S. Van Pelt, Enzyme immobilisation in biocatalysis: why, what and how, Chem. Soc. Rev., 42 (2013) 6223#8211;6235. [4] X.-Z. Zhang, D.-Q. Wu, C.-C. Chu, Synthesis, characterization and controlled drug release of thermosensitive IPN#8211;PNIPAAm hydrogels, Biomaterials, 25 (2004) 3793#8211;3805. [5] Y. Chen, P. Gai, J. Xue, J.-R. Zhang , J.-J. Zhu, An ”ON#8211;OFF” switchable power output of enzymatic biofuel cell controlled by thermal-sensitive polymer, Biosens. Bioelectron., 74 (2015) 142#8211;149. [6] T.L. Sun, G.J. Wang, L. Feng, B.Q. Liu, Y.M. Ma, L. Jiang, D.B. Zhu, Reversible Switching between Superhydrophilicity and Superhydrophobicity, Angew. Chem. Int. Ed., 43 (2004) 357#8211;360. [7] X. Zhao, Y. Liu , J. Lu, J. Zhou, J. Li, Temperature-Responsive Polymer/Carbon Nanotube Hybrids: Smart Conductive Nanocomposite Films for Modulating the Bioelectrocatalysis of NADH, Chem. Eur. J., 18 (2012) 3687#8211;3694. [8] J.H. Zhou, J. Liu, G. Wang, X.B. Lu, Z.H. Wen, J.H. Li, Poly(N-isopropylacrylamide) Interfaces with Dissimilar Thermo-responsive Behavior for Controlling Ion Permeation and Immobilization, Adv. Funct. Mater., 17 (2007) 3377#8211;3382. [9] U.G. Spizzirri, F. Iemma, F. Puoci, F. Xue, W. Gao, G. Cirillo, M. Curcio, O.I. Parisi, N. Picci, Synthesis of hydrophilic microspheres with LCST close to body temperature for controlled dual-sensitive drug release, Polym. Adv. Technol., 22 (2011) 1705#8211;1712. [10] L. Klouda, A.G. Mikos, Thermoresponsive hydrogels in biomedical applications, Eur. J. Pharm. Biopharm., 68 (2008) 34#8211;45.

3. 毕业设计（论文）进程安排

2016.12.1~2017.1.15 指导学生查阅相关文献，做好开题前期工作 2017.1.16~2017. 2.15 在广泛查阅资料的基础上，完善课题研究方案，完成外文翻译、文献综述和开题报告等 2017.2.16~2017. 3.1 熟悉实验室准备仪器药品，确定实验方案 2017.3.2~2017. 4.1 (1) 采用电化学方法制备PNIPAm水凝胶 (2) 探索最佳的聚合参数 2017.4.2~2017. 5.15 (3) 采用合适的方法修饰PNIPAm水凝胶 (4) 电化学法和光谱法表征载药 (5) 电镜表征载药前后的表面形貌 2017.5.16~2017. 5.30 整理和分析数据，完成毕业论文写作，进行毕业论文的审阅和修改完善 2017.6 答辩及录入成绩阶段：完成毕业设计（论文）的答辩资格审查、答辩、成绩评定及成绩输入工作。