1. 毕业设计（论文）的内容和要求

1、 课题内容

1) 高效液相色谱串联质谱（lc-ms/ms）检测技术原理；

2) 方法学验证实验的目的、实验过程和原理；

2. 参考文献

[1] salamanna f, pagani s, maglio m, et al. estrogen-deficient osteoporosis enhances the recruitment and activity of osteoclasts by breast cancer cells [j]. histology and histopathology, 2016, 31(1): 83-93.

[2] ma b, liu j, zhang q, et al. metabolomic profiles delineate signature metabolic shifts during estrogen deficiency-induced bone loss in rat by gc-tof/ms [j]. plos one, 2013, 8(2): e54965-1-e54965-10.

[3] ramoz n, versini a, gorwood p. anorexia nervosa and estrogen receptors [j]. vitamins amp; hormones, 2013, 92: 141-163.

3. 毕业设计（论文）进程安排