1. 毕业设计（论文）的内容和要求

颅内压(icp)是指颅腔内容物对颅腔壁上所产生的压力，中风或外部创伤造成的脑损伤可能引起颅内压升高，会造成潜在伤害甚至造成死亡。

成年人正常icp在5-15mmhg，持续的大于20mmhg被认为是病态的，当超过40mmhg则会是致命的。

由于icp是预后的重要因素和预测指标，其监测被用于指导临床治疗。

2. 参考文献

[1] 杨勇, 杨义, 王任直. 颅内压监测技术的进展[J]. 中国微侵袭神经外科杂志, 2008, 13(6):284-286. [2] 有创颅内压监测在重型颅脑损伤患者术后治疗中的价值[J]. 检验医学与临床, 2016, 13(12):1631-1632. [3] Wang J X , Hu X , Shadden S C . Data-augmented modeling of intracranial pressure[J]. 2018. [4] Williamson M R , John R F , Colbourne F . Measurement of Intracranial Pressure in Freely Moving Rats[J]. 2018. [5] Kumaran R S , Greger B , Christen J B , et al. Design and evaluation of a low cost intracranial pressure monitoring system.[C]// Engineering in Medicine Biology Society. IEEE, 2016. [6] Mohamad M , Soin N , Ibrahim F . Design of a high sensitivity MEMS piezoresistive intracranial pressure sensor using three turns meander shaped piezoresistors[C]// International Conference on Bio-engineering for Smart Technologies. IEEE, 2017. [7] F, A R S H , Soin N , Ibrahim. Analysis of MEMS Diaphragm of Piezoresistive Intracranial Pressure Sensor[C]// Biomedical Engineering Sciences. IEEE, 2015. [8] Leggate J R S , Piper I R , Robertson I , et al. Clinical and Laboratory Evaluation of the Camino Intracranial Pressure Monitoring System[M]// Intracranial Pressure VII. Springer Berlin Heidelberg, 1989. [9] Qiuxu W , Chaochao H , Jian C , et al. Wireless Passive Intracranial Pressure Sensor Based on a Microfabricated Flexible Capacitor[J]. IEEE Transactions on Electron Devices, 2018, 65(6):2592-2600. [10] Hanjun J , Yanshu G , Zeliang W , et al. Implantable Wireless Intracranial Pressure Monitoring Based on Air Pressure Sensing[J]. IEEE Transactions on Biomedical Circuits and Systems, 2018:1-12. [11] Zhong J , Dujovny M , Park H K , et al. Advances in ICP monitoring techniques[J]. Neurological Research, 2003, 25(4):339-350. [12] Harary M , Dolmans R G F , Gormley W B . Intracranial Pressure Monitoring#8212;Review and Avenues for Development[J]. Sensors, 2018, 18(2):465. [13]徐柯贝, 肖泉, 叶劲. 颅内压监测技术临床应用的研究进展[J]. 中国临床新医学, 2013, 6(12):1233-1238. [14]张拥波. 颅内压监测技术研究进展[J]. 中国急救医学, 2002, 22(2):122-123. [15]孟令虎, 李斌. 持续颅内压监测与临床应用[J]. 中国医学创新, 2013(17):155-156.

3. 毕业设计（论文）进程安排

12.1-12.31 与导师会面，布置论文题目，查阅资料1.1-1.19 完成开题报告3.5-4.5 完成翻译，检索查看相关文献4.5-5.5 时间漂移测试和校正5.5-5.30数据整理，论文撰写，毕业答辩准备 6.1-6.10 准备论文答辩