1. 毕业设计（论文）的内容和要求

1.查阅石墨烯量子点以及姜黄素胶束制备的相关文献，了解石墨烯量子点合成和姜黄素胶束制备的难点和和重要性；2.初步验证方法的可行性；3.进行实验方法的构建，包括实验条件的优化以及实验数据的处理等； 4.归纳所得实验结论及对实验进行展望。

2. 参考文献

[1] Melgosa, R., Sanz, M. T., Aacute;ngela G. Solaesa, Bucio, S. L., Beltr#225;n, S., Enzymatic activity and conformational and morphological studies of four commercial lipases treated with supercritical carbon dioxide, J Supercrit Fluid., 2015, 97, 51-62. [2] Bubalo, M. C., Tu#353;ek, A. J., Vinkovi#320;, M., Rado#353;evi#320;, K., Sr#320;ek, V. G., Redovnikovi#320;, I. R., Cholinium-based deep eutectic solvents and ionic liquids for lipase-catalyzed synthesis of butyl acetate, J Mol Catal-B Enzym., 2015, 122, 188-198. [3] Durand, E., Lecomte, J., Villeneuve, P., Deep eutectic solvents: synthesis, application, and focus on lipase-catalyzed reactions, Eur J Lipid Sci Tech., 2013, 115, 4, 379-385. [4] Gupta, R., Gupta, N., Rathi, P., Bacterial lipases: an overview of production, purification and biochemical properties, Appl Microbiol Biot., 2004, 64, 6, 763-781. [5] Lotti, M., Alberghina, L., Lipases: Molecular Structure and Function. Industrial Enzymes, 2007. [6] Bancerz, R., Ginalska, G., Fiedurek, J., Gromada, A., Cultivation conditions and properties of extracellular crude lipase from the psychrotrophic fungus penicillium chrysogenum, 9′, J Ind Microbiol Biotechnol., 2005, 32, 6, 253-260. [7] Jaeger, K. E., Reetz, M. T., Microbial lipases form versatile tools for biotechnology, Trends Biotechnol., 1998, 16, 9, 396-403. [8] Miranda, A. S. D., Miranda, L. S. M., Souza, R. O. M. A. D., Lipases: valuable catalysts for dynamic kinetic resolutions, Biotechnol Adv., 2015, 33, 5, 372-393. [9] Chanmee, W., Chaicharoenpong, C., Petsom, A., Lipase inhibitor from fruits of solanum stramonifolium jacq, Food Nutrition Sciences.,2013, 4, 5, 554-558. [10] Amitesh, Aggarwal, Saurabh, Srivastava, Velmurugan., Newer perspectives of coronary artery disease in young, World Journal of Cardiology., 2016, 8, 12, 728-734. [11] Yuritzi, Santill#225;n-Hern#225;ndez, Enory, Almanza-Miranda, Winnie, Kendrick, et al., Novel lipa mutations in mexican siblings with lysosomal acid lipase deficiency, World Journal of Gastroenterology., 2015, 21, 3, 1001-1008. [12] Chen, S., Yu, Y. L., Wang, J. H., Inner filter effect-based fluorescent sensing systems: a review, Anal Chim Acta., 2018, 999, 13-26. [13] Zheng, M., Xie, Z. G., Qu, D., Li, D., Du, P., Jing, X. B., et al., On-off-on fluorescent carbon dot nanosensor for recognition of chromium(vi) and ascorbic acid based on the inner filter effect, Acs Appl. Mater. Interfaces., 2013. 5, 24, 13242-13247. [14] Yang, S., Wang, C. Y., Liu, C. H., Wang, Y. H., Xiao, Y., Li, J. S., et al., Fluorescence modulation by absorbent on solid surface: an improved approach for designing fluorescent sensor, Anal. Chem., 2014, 86, 15, 7931-7938. [15] Liu, H. J., Ming, L., Xia, Y. N., Ren, X. Q., A turn-on fluorescent sensor for selective and sensitive detection of alkaline phosphatase activity with gold nanoclusters based on inner filter effect, Acs Appl. Mater. Interfaces., 2017, 9, 1, 120#8722;126. [16] Si, F. F., Zou, R. B., Jiao, S. S., Qiao, X. S., Guo, Y. R., Zhu, G. N., Inner filter effect-based homogeneous immunoassay for rapid detection of imidacloprid residue in environmental and food samples, Ecotox Environ Safe., 2018, 148, 862-868. [17] Li, G. L., Fu, H. L., Chen, X. J., Gong, P. W., Chen, G., Xia, L., et al., Facile and sensitive fluorescence sensing of alkaline phosphatase activity with photoluminescent carbon dots based on inner filter effect, Anal Chem., 2016, 88, 5, 2720-2726. [18] Zhang, J. Y., Lu, X. M., Lei, Y., Hou, X. D., Wu, P., Exploring the tunable excitation of QDs to maximize the overlap with the absorber for inner filter effect-based phosphorescence sensing of alkaline phosphatase, Nanoscale., 2017, 9, 40, 15606-15611. [19] Kong, W. H., Wu, D., Xia, L., Chen, X. F., Li, G. L., Qiu, N. N., et al., Carbon dots for fluorescent detection of α-glucosidase activity using enzyme activated inner filter effect and its application to anti-diabetic drug discovery, Anal Chim Acta., 2017, 973, 91-99. [20] Lu, S. M., Li, G. L., Lv, Z. X., Qiu, N. N., Kong, W. H., Gong, P. W., et al., Facile and ultrasensitive fluorescence sensor platform for tumor invasive biomaker β-glucuronidase detection and inhibitor evaluation with carbon quantum dots based on inner-filter effect, Biosens Bioelectron., 2016, 85, 358-362.

3. 毕业设计（论文）进程安排

以实验进程而定