1. 毕业设计（论文）的内容和要求

经过广泛论证，我们知道花青染料的结构上特点是：共轭链上带有吸电子与给电子基团,且色泽大多呈现红、橙红颜色，同时具有摩尔吸光度大的性质。

由于，吸电子基团和给电子基团都含有氮原子,对质子敏感,具有非常好的酸致变色的特性。

当有外来物种的侵入时，其改变吸、供电子基团电子结构后,通常改变了它的吸收光能的性质，从而实现光开关的作用。

2. 参考文献

[1] 贾美琳,陈庆,蒋宛莉,谷威,王筱梅. 喹啉盐与吡啶盐花青染料分子酸致变色行为的研[J].信息记录材料.2009（05）. [2]刘晁清,王玲玲,肖经纬,宋国梁,刘浩.Er3 掺杂的氧化钇纳米上转化发光性质的研究[J].材料导报.2006,11(20):47-49. [3]李雅丽,孟燕.几种花青染料的合成及分离[J].西安工程学院学报.1999,09(21):91-93. [4] Wang C, Cheng L, Liu Y, Wang X, Ma X, Deng Z, et al. Imaging-guided pHsensitive photodynamic therapy using charge reversible upconversion nanoparticles under near-infrared light. Adv Funct Mater 2013;23:3077-86. [5] Cheng L, Yang K, Li Y, Chen J, Wang C, Shao M, et al. Facile preparation of multifunctional upconversion nanoprobes for multimodal imaging and dualtargeted photothermal therapy. Angew Chem Int Ed 2011;50:7385-90. [6] Zhang C, Zhou H-P, Liao L-Y, Feng W, Sun W, Li Z-X, et al. Luminescence modulation of ordered upconversion nanopatterns by a photochromic diarylethene: rewritable optical storage with nondestructive readout. Adv Mater 2010;22:633-7. [7] Feng W, Han C, Li F. Upconversion-nanophosphor-based functional nanocomposites. Adv Mater 2013;25:5287-303. [8]Chunwei Yu,Ying Wang,Ke Xu.Characterization of a highly Cu2 -selective fluorescent probe derived from rhodamine B[J].Dyes Pigm,2013,96,38. [9]J Pan,P Zhan,M Hu.A fluorescent rationmetric chemodosimeter for Cu2 based on TBET and its application in living cells[J].Org Lett.,2013,15,492 [10]M Kumar,N Kumar,V.Bhalla.Highly selective fluorescence turn-on chemodosimeter based on rhodamine for nanomolar detection of copper ions[J].Org Lett.,2012,14,406 [11]J Liu,C Li,F Li.Fluorescence turn-on chemodosimeter-functionalized mesoporous silca nano- particles and their application in cell imaging[J].J.Mater.Chem.,2011,21,7175. [12]Puhui Xie,Fengqi Guo,Dan Li.A Cu2 chemodosimeter based on amplified fluorescence in the red region[J].J.Lumin.,2011,131,104. [13]D Wang,Y Shiraishi,T Hirai.A BODIPY-based fluorescent chemodosimeter for Cu(II) driven by an oxidative dehydrogenation mechanism[J].Chem,Commun.,2011,47,2673. [14] Fenton, H H. On a new reaction of tartaric acid [J]. Chem. News., 1876, 33, 190. [15] Benesi H A, Hildebrand J H. A spectrophotometric investigation of the interaction of iodine with aromatic hydrocarbons [J]. J. Am. Chem. Soc., 1949, 71(8): 2703-2707. [16] Yang Y K, Ko S K, Shin I, et al. Synthesis of a highly metal-selective rhodaminebased probe and its use for the in vivo monitoring of mercury [J]. Nature Protocols. 2007, 2(7): 1740-1745. [17] Taki M, Iyoshi S, Ojida A, et al. Development of highly sensitive fluorescent probes for detection of intracellular copper(I) in living systems [J]. J. Am. Chem. Soc., 2010, 132(17): 5938-5939. [18] Chen X, Ko S K, Kim M J, et al. A thiol-specific fluorescent probe and its application for bioimaging [J]. Chem. Commun., 2010, 46(16): 2751-2753.

3. 毕业设计（论文）进程安排

2019.1.2-2019.3.1 查阅资料，完成开题报告和任务书 2019.3.2-2019.3.10 确定方案，学习实验过程和操作 2019.3.11-2019.4.30 独立实验，合成产品并进行光谱表征 2019.5.1-2019.5.30 数据整理，书写论文，制作PPT 2019.5.30-2019.6 修改论文并完成答辩