1. 毕业设计（论文）的内容和要求

1.熟悉基本的实验操作，理解实验的基本内容；2.能做做到流利阅读文献， 掌握文献内容；3.熟练运用各种信息平台查阅相关信息；4.了解当下有机化学方 向中砜基自由基加成环化的内容，了解砜基自由基的背景以及意义；5.熟悉并掌握 砜基自由基环化的机理。

2. 参考文献

1].Li, M.; Wang, S. W.; Wen, L. R.; et al. Electrochemical reactions of organic compounds in liquid ammonia. III. Reductive alkylation of quinoline J. Heterocycl. Chem.， 2005, 42, 925 - 975； [2].D. M. Connors .; N. S.Erratum.; Cluster Glass Transition of Ultrasoft-Potential Fluids at High Density [Phys. Rev. Lett. 117, 165701 (2016)] Goroff, Org. Lett., 2016, 18, 4262#8211;4265; [3].S. Song.; X. Li.; X. Sun.; et al. Comment on "Virtues and limitations of Pittsburgh green for ozone detection" by C. C. Beltran, E. A. Palmer, B. R. Buckley and F. Iza, Chem. Commun., 2015, 51, 1579 Green Chem., 2015, 17,3285#8211;3287; [4].Sevenard D V.; Sosnovskikh V Y.; Kolomeitsev A A.; Coordinate Regulation of TET2 and EBNA2 Controls the DNA Methylation State of Latent Epstein-Barr Virus J . Tet rahedron Letters，2003, 44 : 7623 -7627; [5].Muralidharan K.; Chakraborty R.; Shreeve J M.D#233;j#224;-r#234;v#233;: Prior dreams induced by direct electrical brain stimulation J. Fluo Chem，2004, 125 : 1967 -1968; [6].Ma J A.; Dominique C.; Mild Electrophilic Trifluoromethylation of Ketoesters and Silyl Enol Ethers with 5-Trifluoro Methyldibenzothiophenium Tetrafluoroborate J. Orga Chem，2003, 68 : 8726 - 8729; [7].Billard T.; Bruns S.; Langlois B R.; New Stable Reagents for the Nucleophilic Trifluoromethylation. 1. Trifluoromethylation of Carbonyl Compounds with N-Formylmorpholine Derivatives J. Org Lett, 2000, 2( 14): 2101 -2103; [8].Muller K.; Faeh C.; Diederich F.; Fluorine in pharmaceuticals：looking beyond intuition J. Science，2007(317): 1881-1886.; [9].Purser S.; Moore P R.; Swallow S.; Fluorine in medicinal chemistry J. ChemSocRev，2008(37): 320-330; [10].Jeschke P.; The unique role of fluorine in the design of active ingredients for modern crop production J. Chem Bio Chem，2004 (5)： 570-589; [11].Fukuzawa, S.; Nakanishi, A.; Fujinami, T.; Sakai, S.; Samarium Diiodide-Induced Couplings of Carbonyl Compounds with Methoxyallene Leading to 4-Hydroxy 1-Enol Ethers J. Chem. Soc., Perkin Trans. 1 1988, 1669#8722;1674; [12].Bey, P.; Gerhart, F.; Jung, M. Stereoselective Nucleophilic Monofluoromethylation of N-(tert-Butanesulfinyl)imines with Fluoromethyl Phenyl Sulfone J. Org. Chem. 1986, 51, 2835#8722;2838; [13].Taniguchi,Y.; Fujii, N.; Takaki, K.; Fujiwara, Y.Three-Component Coupling of Acylphosphonates and Two CarbonylCompounds Promoted by Low-Valent Samariums:#8201; One-Pot Synthesis of β-Hydroxyphosphonates J. Organomet. Chem. 1995, 491, 173#8722;179; [14].Danowitz, A. M.; Taylor, C. E.; Shrikian, T. M.; Mapp, A. K.Synthesis of Functionalized Allenamides from Ynamides by Enolate Claisen Rearrangement Org. Lett. 2010, 12, 2574#8211;2577; [15].For a review of palladium-catalyzed couplings of vinyl compounds, see:#8201; Nicolaou, K. C.; Sorensen, E.Palladium-Catalyzed α-Vinylation of Carbonyl Compounds J.Classics in Total Synthesis; Wiley-VCH:#8201; Weinheim, Germany, 1996; 565#8722;631;

3. 毕业设计（论文）进程安排

毕业设计进程安排: 2018.1.9 进入实验室，交待相关事宜，安排实验任务； 2018.1.9-2018.3.20 查阅文献，准备开题报告； 2018.3.20 提交开题报告。

2018.3.20-2018.3.31 合成试验所需原料； 2018.4.1-2018.5.29 选择相应的催化剂催化反应进行，筛选条件，优化反应条件；2018.5.30-2018.6.4 实验数据整理与分析。

20188.6.4-2018.6.10 撰写论文。