1. 研究目的与意义（文献综述）

1、目的及意义（含国内外的研究现状分析）

cancer is one of the diseases that threaten human life and health. chemotherapy is one of the most effective methods for the treatment of cancer, and it is also an indispensable and effective method for the treatment of cancer. however, most of the chemotherapeutic drugs in clinical use, there are many problems, such as water solubility and poor stability, poor selectivity, high toxicity, distribution of lack of target and short circulation time in vivo, only the curative effect is low, but also easy to damage to the human body immunity, damage to the normal body, cause serious side effects, bring the pain to the patient. the best way to reduce the side effects of drugs, reduce the dosage of drugs, and enhance the efficacy of drugs in the treatment of antitumor drugs. therefore, the method of tumor target therapy has been widely studied in the field of cancer treatment, with its high selectivity and low toxicity.

2. 研究的基本内容与方案

the target is the structural characterization of the drug and antitumor activity in vitro ;

the synthesized adriamycin dual effect pro-drug could inhibit the growth of human hepatoma hepg2 cells.

in the synthesis of doxorubicin pro-drug effect, we can find that researchers use the alpha linolenic acid can prevent breast cancer activity and antitumor activity of tumor occurrence and metastasis inhibition of tumor and with active targeting of the advantages of combination of hydrazone bond cleavage constructed.

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3. 研究计划与安排

第1－3周：查阅相关文献资料，明确研究内容，了解课题的研究现状。

确定方案，完成开题报告。

第4－6周：完成药物收集及掌握相关环境响应释药机制的原理。

4. 参考文献（12篇以上）

参考文

[1] ciccoli Ｒ，sahi s，singh s，et al． oxygenation by cox-2( cyclo-oxygenase-2) of 3-hete ( 3-hydroxyeicosatetrae-noic acid) ，a fungal mimetic of arachidonic acid，producesa cascade of novel bioactive 3-hydroxyeicosanoids［j］．biochem j，2005，390( pt 3) : 737-747