论文总字数：20643字

摘 要

N-烷基-1-脱氧野尻霉素（DNJ）是一种发现于桑叶中的活性生物碱，具有强力的α-葡萄糖苷酶抑制功能，进而抑制人体糖分的转化，且发生低血糖以及其它副作用的可能性远低于其它降血糖药物。此外，本品还具有抗癌，减肥，降血脂，抗病毒等多种功效。

本文的主要任务是N-烷基-1-脱氧野尻霉素的粗产品的精制车间的设计。首先，对N-烷基-1-脱氧野尻霉素精制的各种工艺进行了仔细的筛选，选出最佳的工艺路线。具体流程为：将上游所得中间产物进行氢化，再依次经过KOCH®-MF-618卷式微滤膜分离，001*7(H)型离子交换树脂柱纯化，KOCH®8040-S-410节能型纳滤膜浓缩，粗结晶，活性炭脱色，精结晶，流化床干燥器干燥，并详述每一步的操作要求。然后进行相关的物料衡算和能量衡算，根据计算结果，选择适合的设备，并开展厂房设计的工作，该工厂具有自动化强，生产效率高等特点。

关键词：N-烷基-1-脱氧野尻霉素 氢化 微滤 离子交换 膜浓缩

Technological design of 5 tons N-alkyl-1-deoxynojirimycin production line per year (finished product refining workshop)

Abstract

N-alkyl-1-deoxynojirimycin (DNJ) is an active alkaloid found in mulberry leaves, having Strong inhibition of alpha-glucosidase, and then inhibit the transformation of sugar in human body, the possibility of hypoglycemia and other side effects is much lower than other hypoglycemic drugs, good safety, Using of this product can not change the normal diet structure. Modern pharmacological research shows that this product also has many effects, such as anti-cancer, weight loss, blood lipid reduction, anti-virus and so on. It has high research value.

The main task of this paper is to design the refining workshop for crude products of N-alkyl-1-deoxynojirimycin. Firstly, various refining processes of N-alkyl-1-deoxynojirimycin were carefully screened and the optimum process route was selected. Secondly, the selected process route is described in detail. First, the crude products obtained upstream are hydrogenated, then it is separated by composite ultrafiltration membrane, purified by acid ion exchange resin column, decolorized, concentrated, crystallized and dried by activated carbon, and the operation requirements of each step are described in detail. Then the relevant material balance and energy balance are carried out. According to the calculation results, the suitable equipment is selected and the workshop of refinement workshop is designed. Finally, according to the selected equipment and various parameters, the process flow with control points, the selection of main equipment, the list of main equipment, the layout of equipment and the elevation of equipment are designed.

Key words: N-alkyl-1-deoxynojirimycin, hydrogenated, microfiltration, ion exchange, concentration

目 录

第一章 项目设计概述 1

1.1 项目名称 1

1.2 产品方案 1

1.2.1 产品概述 1

1.2.2生产方法 1

1.2.3产品标准 1

1.3 厂址选择 1

1.4 本工段的主要任务 2

第二章 工艺流程设计 3

2.1 工艺流程的确定 3

2.2.1工艺流程图 4

2.2生产流程简述 4

2.2.1 氢化反应 4

2.2.2 膜分离 4

2.2.3离子交换树脂 5

2.2.4 膜浓缩 6

2.2.5粗结晶 7

2.2.6 脱色 7

2.2.7 精浓缩结晶 7

2.2.8 干燥 8

2.3 工艺所需原材料及说明 8

2.3.1NaOH溶液 8

2.3.2氨水 8

2.3.3稀盐酸 8

2.3.4烧碱 8

2.3.5活性炭 8

2.3.6浓硫酸 9

2.3.7钯炭 9

2.3.8活性镍 9

第三章 物料衡算和能量衡算 10

3.1 物料衡算 10

3.1.1 年产5吨N-烷基-1-脱氧野尻霉素精制工段各步骤的物料衡算 10

3.1.2氢化阶段的物料衡算 11

3.1.3 微滤阶段的物料衡算 11

3.1.4离子交换阶段的物料衡算 12

3.1.5膜浓缩阶段的物料衡算 14

3.1.6粗结晶阶段的物料衡算 15

3.1.7过滤阶段的物料衡算 15

3.1.8粗品溶解脱色阶段的物料衡算 16

3.1.9精浓缩结晶阶段的物料衡算 16

3.1.10干燥阶段的物料衡算 18

3.2能量衡算....................................................18

3.2.1粗结晶阶段的能量衡算 19

3.2.2脱色阶段的能量衡算 20

3.2.3精浓缩结晶阶段的能量衡算 20

3.2.4干燥阶段的能量衡算 21

3.3 物料衡算表 21

3.4能量衡算表 22

第四章 主要设备选型 25

4.1氢化设备的选型 25

4.2微滤膜分离设备的选型 25

4.3离子交换柱的选型 25

4.4膜浓缩设备的选型 25

4.5粗结晶设备的选型 26

4.5.1结晶釜的选型计算 26

4.5.2结晶器加热器的选型计算 26

4.5.3结晶器最终选型说明计算 27

4.6离心机的选型 27

4.7脱色罐的选型 27

表4-2 脱色罐详细规格 27

4.8精浓缩结晶阶段的选型计算 28

4.9干燥工段沸腾干燥器选型 28

4.10 主要设备一览表 29

第五章 车间布置设计 30

5.1车间的布置 30

5.1.1厂房的整体布置 30

5.1.2厂房的平面布置 30

5.2设备的布置 30

5.2.1罐体的布置 30

5.2.2换热器的布置 30

5.2.3泵的布置 31

5.2.4离心机的布置 31

总结 32

参考文献： 33

致谢 35

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