1. 毕业设计（论文）的内容和要求

1．文献查阅 掌握文献查阅的一般方法，学会使用计算机在中国期刊网、维普数据库、超星数字图书馆、美国化学学会（acs）数据库、英国皇家化学学会（rcs）数据库、elseiver、isi chemistry server、ei、ca 等检索资源上查阅关于oca合成的相关文献。

2．文献阅读及综述 阅读与课题相关的外文及中文文献，了解国内外的研究动态，撰写文献综述。

3．明确实验任务，拟定实验方案 根据所查阅文献的内容，确定实验内容及方案，拟定科学可行的研究计划。

2. 参考文献

[1] Yuan G, Yuan Y, Xu K, et al. Biocompatible PEGylated Fe3O4 nanoparticles as photothermal agents for near-infrared light modulated cancer therapy [J]. International journal of molecular sciences, 2014, 15(10): 18776-18788. [2] 吴朝辉,曾蕾,贺全国.磁性铁氧化物纳米粒子制备及其体内应用研究[J].化学研究与应用,2010,22(04):401-414 [3] 刘波洁,李学毅,陈威,刘忍肖,葛广路.氧化铁磁性纳米粒子的表面配体交换及相转移[J].物理化学学报,2010,26(03):784-788. [4] 饶通德.氧化铁磁性纳米粒子的表面修饰及应用[J].化工文摘,2009(02):59-62. [5] 詹凤,范君伟,李成魁,严彪.水热法制备纳米Fe_3O_4磁性颗粒[J].金属功能材料,2012,19(01):20-25. [6] Gupta A K, Gupta M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications[J]. Biomaterials, 2005, 26(18): 3995-4021. [7] Thomas L A, Dekker L, Kallumadil M, et al. Carboxylic acid-stabilised iron oxide nanoparticles for use in magnetic hyperthermia[J]. Journal of Materials Chemistry, 2009, 19(36): 6529-6535. [8] Chen D, Xu R. Hydrothermal synthesis and characterization of nanocrystalline Fe 3 O 4 powders[J]. Materials Research Bulletin, 1998, 33(7): 1015-1021. [9] Hyeon T, Lee S S, Park J, et al. Synthesis of highly crystalline and monodisperse maghemite nanocrystallites without a size-selection process[J]. Journal of the American Chemical Society, 2001, 123(51): 12798-12801. [10] Basak S, Chen D R, Biswas P. Electrospray of ionic precursor solutions to synthesize iron oxide nanoparticles: modified scaling law[J]. Chemical engineering science, 2007, 62(4): 1263-1268. [11] Morales M P, Veintemillas-Verdaguer S, Montero M I, et al. Surface and internal spin canting in γ-Fe2O3 nanoparticles[J]. Chemistry of Materials, 1999, 11(11): 3058-3064. [12] 张宝林, 张辉阳. 超顺磁性氧化铁纳米粒子在脑磁共振成像中的应用[D]. , 2011. [13] Hao R, Xing R, Xu Z, et al. Synthesis, functionalization, and biomedical applications of multifunctional magnetic nanoparticles[J]. Advanced Materials, 2010, 22(25): 2729-2742. [14] 陈月,陈宝安.磁性氧化铁纳米颗粒在肿瘤靶向治疗中的应用及进展[J].癌症,2010,29(01):125-128. [15] Chen Z P, Zhang Y, Zhang S, et al. Preparation and characterization of water-soluble monodisperse magnetic iron oxide nanoparticles via surface double-exchange with DMSA[J]. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2008, 316(1): 210-216. [16] Xie J, Xu C, Kohler N, et al. Controlled PEGylation of monodisperse Fe3O4 nanoparticles for reduced non‐specific uptake by macrophage cells[J]. Advanced Materials, 2007, 19(20): 3163-3166. [17] De Palma R, Peeters S, Van Bael M J, et al. Silane ligand exchange to make hydrophobic superparamagnetic nanoparticles water-dispersible[J]. Chemistry of Materials, 2007, 19(7): 1821-1831.

3. 毕业设计（论文）进程安排

2017.12.25~2017.12.12 确定课题，下达任务书，查阅文献，做好开题前期工作 2018.1.12~2018.3.19 查阅文献，做出研究方案，完成外文翻译和开题报告，开始实验 2018.3.20~2018.3.24 总结前一阶段工作，完成中期自检和中期汇报，确定下一阶段目标 2018.3.25~2018.4.30 扩展课题研究范围，改进实验方案，对数据整理分析，撰写论文 2018.5.1~2018.6.7 完善毕业论文 2018.6.7~2018.6.14 准备毕业答辩