1. 毕业设计（论文）的内容和要求

1．文献查阅 掌握文献查阅的一般方法，学会使用计算机在中国期刊网、维普数据库、超星数字图书馆、美国化学学会（acs）数据库、英国皇家化学学会（rcs）数据库、elseiver、isi chemistry server、ei、ca 等检索资源上查阅有关原料合成的相关文献。

2．文献阅读及综述 阅读与课题相关的外文及中文文献，了解国内外的研究动态，撰写文献综述。

3．明确实验任务，拟定实验方案 根据所查阅文献的内容，确定实验内容及方案，拟定科学可行的研究计划。

2. 参考文献

[1] Ohno, S; Takamoto, K; Fujioka, H; Arisawa, M, Cycloisomerization between Aryl Enol Ether and Silylalkynes under Ruthenium Hydride Catalysis: Synthesis of 2,3-Disubstituted Benzofurans[J].Organic Letters, 2017, 19, 2422-2425. Dorel, Ruth; Echavarren, Antonio M. Gold-Catalyzed Reactions via Cyclopropyl Gold Carbene-like Intermediates.[J] Journal of Organic Chemistry, 2015, 80, 7321-7332. Obradors, C; Echavarren, A M. Gold-Catalyzed Rearrangements and Beyond[J]. Accounts of Chemical Research, 2014, 47, 902-912. [2] Huber, F; Kirsch, S F. NIS-Mediated Electrophilic Cyclization of 3-Silyloxy-1,n-enynes[J]. Journal of Organic Chemistry, 2013, 78, 2780-2785. [3] Aubert, C; Buisine, O; Malacria, M. The Behavior of 1,n-Enynes in the Presence of Transition Metals[J].Chemical Reviews. 2002, 102, 813-834. [4] Wakamatsu H, Sakagami M, Hanata M. Ring-Closing Metathesis of Ene-Ynamide: Application to the Synthesis of Medium-Sized Cyclic Dienamide[J]. Macromolecular Symposia, 2010, 293: 5-9. [5] Son S, Kim S Y, Chung Y K. Rhodium-Catalyzed Rearrangement Reaction of Azabicyclo[4.1.0]heptenes bearing Cyclopropyl and Aryl Groups to Arylhexahydroisoquinolines[J]. ChemistryOpen, 2012, 1(4): 169-172. [6] Ni Z, Giordano L, Tenaglia A. Cyclobutene formation in PtCl2-catalyzed cycloisomerizations of heteroatom-tethered 1,6-enynes[J]. Chemistry-A European Journal, 2014, 20(37): 11703-11706. [7] Shinde, M P.; Wang, X; Kang, E J; Jang, H-Y. Platinum-Catalyzed Hydrogenative Cyclization of Yne-Enones, Yne-Aldehydes, and Yne-Dienes. European Journal of Organic Chemistry, 2009, 35, 6091-6094, S6091/1-S6091/5. [8] Park J H, Cho Y, Chung Y K. Rhodium-catalyzed Pauson-Khand-type reaction using alcohol as a source of carbon monoxide[J]. Angewandte Chemie International Edition, 2010, 49(30): 5138-5141. [9] Zhu Y-L, Jiang B, Hao W-J, Qiu J-K, Sun J, Wang D-C, Wei P, Wang A-F, Li G; Tu S-J. Catalytic Arylsulfonyl Radical Triggered 1,7-Enyne Bicyclizations[J]. Organic Letters, 2015, 17: 6078#8722;6081. [10] Zhu, Y-L; Jiang, B; Hao, W-J; Wang, A-F; Qiu, J-K; Wei, P; Wang, D-C; Li, G, Tu, S-J. A new cascade halosulfonylation of 1,7-enynes toward 3,4-dihydroquinolin-2(1H)-ones via sulfonyl radical-triggered addition/6-exo-dig cyclization[J]. Chemical Communications, 2016, 52:1907-1910. [11] Wang A-F, Zhu Y-L, Wang, S-L, Hao, W-J, Li G, Tu S-J, Jiang B. Metal-Free Radical Haloazidation of Benzene-Tethered 1,7-Enynes Leading to Polyfunctionalized 3,4-Dihydroquinolin-2(1H)-ones[J]. Journal of Organic Chemistry, 2016, 81(3): 1099-1105. [12] Zhu Y-L, Wang D-C, Jiang, B, Hao, W-J, Wei, P, Wang, A-F, Qiu J-K, Tu S-J. Metal-free oxidative hydrophosphinylation of 1,7-enynes[J]. Organic Chemistry Frontiers, 2016, 3: 385#8211;393. [13] Kong W, Casimiro M, Merino E, Nevado C. Copper-Catalyzed One-Pot Trifluoromethylation/Aryl Migration/Desulfonylation and C(sp2)-N Bond Formation of Conjugated Tosyl Amides[J]. Journal of the American Chemical Society, 2013, 135(39):14480-14483.

3. 毕业设计（论文）进程安排

2018.1.12~2018.3.19 查阅文献，做出研究方案，完成外文翻译和开题报告，开始实验 2018.3.20~2018.3.24 总结前一阶段工作，完成中期自检和中期汇报，确定下一阶段目标 2018.3.25~2018.4.30 扩展课题研究范围，改进实验方案，对 数据整理分析，撰写论文 2018.5.1~2018.6.7 完善毕业论文 2018.6.7~2018.6.14 准备毕业答辩