1. 毕业设计（论文）的内容和要求

探索腺苷酸精制的可行性，比较喷雾干燥和结晶所得产品在质量上的区别，优化所选工艺的条件，确定出最佳的精制工艺

2. 参考文献

[1] Bingham A L, Hughes D S, Hursthouse M B, et al. Over one hundred solvates of sulfathiazole [J]. Chem Commun. 2001, 7(7): 603-604. [2] Blagden N, Matas M D, Gavan P T, et al. Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates [J]. Adv Drug Deliv Rev. 2007, 59(7): 617-630. [3] Aitipamula S, Vangala V R, Chow P S, et al. Cocrystal Hydrate of an Antifungal Drug, Griseofulvin, with Promising Physicochemical Properties [J]. Cryst Growth Des. 2012, 12(12): 5858-5863. [4] Harris R K, Ghi P Y, Puschmann H, et al. Structural studies of the polymorphs of carbamazepine, its dihydrate, and two solvates [J]. Org Process Res Dev. 2006, 10(1): 165-165. [5] Higuchi W, Lau P, Higuchi T, et al. Polymorphism and drug availability. Solubility relationships in the methylprednisolone system [J]. J Pharm Sci. 1963, 52(2): 150-153. [6] Babu N J, Nangia A. Solubility Advantage of Amorphous Drugs and Pharmaceutical Cocrystals [J]. Cryst Growth Des. 2011, 11(7): 2662-2679.

3. 毕业设计（论文）进程安排

2016.12.31-2017.2.10 查阅文献，了解基本概念，基本方法，基本思路，研究背景，研究现状，撰写开题报告，初步确立研究方案； 2017.2.10-2017.5.1 全面开展实验研究，完成课题要求的各项指标； 2017.5.1-2017.6 总结课题成果，撰写毕业论文，准备答辩ppt