1. 毕业设计（论文）的内容和要求

1. 完成聚赖氨酸功能化修饰及表征、抗菌和生物相容性测试； 2. 数据整理分析 3. 论文撰写答辩

2. 参考文献

[1] McCrory R, Jones DS, Adair CG, Gorman SP. Pharmaceutical strategies to prevent ventilator-associated pneumonia. J Pharm Pharmacol 2003;55:411e28. [2] Bridgett MJ, Davies MC, Denyer SP, Eldridge PR. Invitro assessment of bacterial adhesion to hydromer-coated cerebrospinal-fluid shunts. Biomaterials 1993; 14:184e8. [3] Salick DA, Pochan DJ, Schneider JP. Design of an injectable beta-hairpin peptide hydrogel that kills methicillin-resistant staphylococcus aureus. Adv Mater 2009;21:4120e3. [4] Landry BK, Nadworny PL, Omotoso OE, Maham Y, Burrell JC, Burrell RE. The kinetics of thermal instability in nanocrystalline silver and the effect of heat treatment on the antibacterial activity of nanocrystalline silver dressings. Biomaterials 2009;30:6929e39. [5] Derache C, Labas V, Aucagne V, Meudal H, Landon C, Delmas AF, et al. Primary structure and antibacterial activity of chicken bone marrow-derived betadefensins. Antimicrob Agents Chemother 2009;53:4647e55. [6] Gelhaus C, Jacobs T, Andra J, Leippe M. The antimicrobial peptide NK-2, the core region of mammalian NK-lysin, kills intraerythrocytic plasmodium falciparum. Antimicrob Agents Chemother 2008;52:1713e20. [7] Liong M, France B, Bradley KA, Zink JI. Antimicrobial activity of silver nanocrystals encapsulated in mesoporous silica nanoparticles. Adv Mater 2009;21:1684e9. [8] Ho CH, Tobis J, Sprich C, Thomann R, Tiller JC. Nanoseparated polymeric networks with multiple antimicrobial properties. Adv Mater 2004;16:957e61. [9] Kuroda K, DeGrado WF. Amphiphilic polymethacrylate derivatives as antimicrobial agents. J Am Chem Soc 2005;127:4128e9. [10] Klibanov AM. Permanently microbicidal materials coatings. J Mater Chem 2007;17:2479e82. [11] Mowery BP, Lindner AH, Weisblum B, Stahl SS, Gellman SH. Structure-activity relationships among random nylon-3 copolymers that mimic antibacterial host-defense peptides. J Am Chem Soc 2009;131:9735e45. [12] Kumar A, Vemula PK, Ajayan PM, John G. Silver-nanoparticle-embedded antimicrobial paints based on vegetable oil. Nat Mater 2008;7:236e41.

3. 毕业设计（论文）进程安排

1. 启动阶段 （2018年12月21日前） 2. 开题阶段 （2019年1月18日前） 3. 实施阶段 （2019年6月3日前） 4. 答辩阶段 （2019年6月14日前）