1. 毕业设计（论文）的内容和要求

静电纺丝法是常见的纳米纤维敷料制备方法之一，其纳米结构可以仿生天然细胞外基质。

目前，大多敷料机械强度低，且抗菌性能差，不能满足实际使用需求。

本课题利用良好的生物可降解性、生物相容性和良好机械强度的聚己内酯，与具有抗菌性的聚赖氨酸天然高分子，通过调节比例制备具有良好机械性能的抗菌纳米纤维敷料。

2. 参考文献

1. Taepaiboon, P., Rungsardthong, U. Supaphol, P. Drug-loaded electrospun mats of poly(vinyl alcohol) fibres and their release characteristics of four model drugs. Nanotechnology 17, 2317#8211;2329 (2006). 2. Nair, L. S. Laurencin, C. T. Polymers as biomaterials for tissue engineering and controlled drug delivery. Adv. Biochem. Eng. Biotechnol 102, 47#8211;90 (2006). 3. Mondrinos, M. J. et al. Porogen-based solid freeform fabrication of polycaprolactone-calcium phosphate scaffolds for tissue engineering. Biomaterials 27, 4399#8211;4408 (2006). 4.HIRAKI J. ε-Polylysine, its development and utilization[J]. Fine Chem, 2000, 29: 18-25. 5.Nie W., Yuan X.Y., Zhao J., Rapidly in situ forming chitosan/ s-polylysine hydrogels for adhesive sealants and hemostatic materials. Carbohydrate Polymers, 2013, 96(1):342-348. 6.Zhou C.C., Li P., Qi X.B, et al., A photopolymerized antimicrobial hydrogel coating derived from epsilon-poly-l-lysine. Biomaterials, 2011，32(11): 2704-2712. 7.Umano M., Uechi K. Uriuda T., et al., Tumor accumulation of epsilon-poly-lysines-based polyamines conjugated with boron clusters. Applied Radiation and Isotopes, 2011，69(12): 1765一1767.

3. 毕业设计（论文）进程安排

1. 2017.12-2018.1 文献调研及路线设计； 2. 2018.2-2018.6 实验合成及工艺路线优化； 3. 2018.6 数据整理及论文写作。