论文总字数：19178字

摘 要

壳聚糖和常用的传统溶剂反应时不仅溶解困难, 并且大部分情况下会产生很大的毒性，且实验产生的费用比较高,而表面活性离子液体（SAILs）是一种绿色有机溶剂，因此设计用SAILs来溶解壳聚糖。

本论文以N-甲基咪唑、氯乙酸酯、正癸烷磺酸钠(1-Decanesulfonic Acid Sodium Salt)等为原料合成[Etmim][C₁₀H₂₁SO₃]。用HNMR确证[Etmim][C₁₀H₂₁SO₃]的结构；采用表面张力、电导率测试确定[Etmim][C₁₀H₂₁SO₃]水溶液的cmc；采用表面张力、电导率、粒径等方法研究壳聚糖-[Etmim][C₁₀H₂₁SO₃]水溶液的cmc，分析壳聚糖在[Etmim][C₁₀H₂₁SO₃]水溶液中的溶解和聚集的性质，阐明[Etmim][C₁₀H₂₁SO₃]与壳聚糖的分子作用机理。本项目将为新型SAILs结构设计，为壳聚糖基生物材料的制备奠定理论与实践基础。

研究发现：用表面张力和电导率两种方法测得[Etmim][C₁₀H₂₁SO₃]的cmc值分别为2.11mmol/L和2.91mmol/L，而用表面张力、电导率和粒径三种方法测得壳聚糖-[Etmim][C₁₀H₂₁SO₃]的cmc值分别为值为1.46mmol/L、0.71mmol/L和1.93mmol/L，cmc值明显降低。

关键词：壳聚糖 表面活性离子液体 表面张力 电导率 临界胶束浓度

Study on solution behavior of chitosan - surface active ionic liquid MEDD

Abstract

Chitosan and conventional solvent reactions are not only difficult to dissolve, and most of the cases will be very toxic and the cost of the experiment is relatively high, and the surface active ionic liquid is a green organic solvent, so designed with sails dissolved chitosan.

This paper synthesized [Etmim][C₁₀H₂₁SO₃] with N-methyl imidazole, chloroacetic acid ester, sodium 1-decanesulfonic acid sodium salt as raw material. The structure of [Etmim][C₁₀H₂₁SO₃] was confirmed by HNMR, the CMC of [Etmim][C₁₀H₂₁SO₃] aqueous solution was determined by surface tension and conductivity test, and the method of surface tension, conductivity and particle size was used to study the CMC of Chitosan- [Etmim][C₁₀H₂₁SO₃] aqueous solution.The dissolution and aggregation properties of chitosan in [Etmim][C₁₀H₂₁SO₃] aqueous solution were analyzed, and the molecular mechanism of [Etmim][C₁₀H₂₁SO₃] and Chitosan were clarified. This project will provide a theoretical and practical basis for the preparation of Chitosan based biomaterials and the design of a new SAILs structure.

Study found that the CMC value of [Etmim][C₁₀H₂₁SO₃] was measured by both surface tension and conductivity of 2.11mmol/L and 2.91mmol/L respectively. The CMC value of chitosan- [Etmim][C₁₀H₂₁SO₃] was measured by three kinds of methods, such as surface tension, conductivity and particle size, was 1.46mmol/L, 0.71mmol/L and 1.93mmol/L, CMC value were decreased obviously.

Key Words: Chitosan; Surface active ionic liquid; surface tension; conductivity; Critical Micelle Concentration

目录

摘要 I

Abstract II

目录 III

第一章 前言 1

1.1选题背景 1

1.2表面活性离子液体SAILs 1

1.2.1 SAILs的性质 1

1.2.2 SAILs的分类 2

1.2.3 SAILs的合成 3

1.2.4 SAILs的应用 4

1.3 壳聚糖 4

1.3.1壳聚糖的概念和结构 4

1.3.2壳聚糖的性能 5

1.3.3壳聚糖的应用 5

1.4 壳聚糖在SAILs中的溶解 6

1.4.1 壳聚糖在ILs中的溶解历程 6

1.4.2 壳聚糖在ILs中的溶解机理 7

1.4.3 壳聚糖在ILs中的溶解作用 7

1.4.4 壳聚糖表面活性剂的合成历程 8

1.4.5壳聚糖表面活性剂的应用 9

1.4.6 壳聚糖在SAILs中的溶解 9

1.5 本文思路 9

第二章 实验内容 10

2.1 实验使用的仪器与药品 10

2.1.1 实验时使用的药品信息 10

2.1.2 实验时使用的仪器信息 10

2.2 实验步骤 11

2.3 研究方式 12

2.3.1 核磁共振氢谱的测定 12

2.3.2 表面张力的测定 12

2.3.3 电导率的测定 12

2.3.4 粒径的测定 12

第三章 结果与分析 13

3.1 [Etmim][C₁₀H₂₁SO₃]的实验数据 13

3.1.1 [Etmim][C₁₀H₂₁SO₃]的核磁共振氢谱 13

3.1.2 [Etmim][C₁₀H₂₁SO₃]的表面张力测试 14

3.1.3 [Etmim][C₁₀H₂₁SO₃]的电导率测试 14

3.2 壳聚糖-[Etmim][C₁₀H₂₁SO₃]的实验数据 15

3.2.1 壳聚糖-[Etmim][C₁₀H₂₁SO₃]的表面张力测试 15

3.2.2 壳聚糖-[Etmim][C₁₀H₂₁SO₃]的电导率测试 16

3.2.3 壳聚糖-[Etmim][C₁₀H₂₁SO₃]的粒径测试 16

第四章 结论与展望 18

4.1 结论 18

4.2 展望 18

参考文献 19

致谢 21

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