1. 毕业设计（论文）的内容和要求

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2. 参考文献

[1]. OBERL?K,CAPDEVILLE M J,BERTHE T,et al.Evidence for a Complex Relationship between Antibiotics and Antibiotic-Resistant Escherichia Coli:From Medical Center Patients to a Receiving Environment[J].Environmental Science Technology,2012,46(3):1859-1868. [2]. STORTEBOOM H,ARABI M,DAVIS J G,et al.Identification of Antibiotic-Resistance-Gene Molecular Signatures Suitable as Tracers of Pristine River,Urban,and Agricultural Sources[J].Environmental Science Technology,2010,44(6):1947-1953. [3]. PRUDEN A,PEI R,STORTEBOOM H,et al.Antibiotic Resistance Genes as Emerging Contaminants:Studies in Northern Colorado 哰J].Environmental Science Technology,2006,40(23):7445-7450. [4]. SHAH S Q,COLQUHOUN D J,NIKULI H L,et al.Prevalence of antibiotic resistance genes in the bacterial flora of integrated fish farming environments of Pakistan and Tanzania[J].Environmental Science Technology,2012,46(16):8672-8679. [5]. TAC肙 M,CORREIA A,HENRIQUES I.Resistance to broad-spectrum antibiotics in aquatic systems:anthropogenic activities modulate the dissemination of blaCTX-M-like genes[J].Applied Environmental Microbiology,2012,78(12):4134-4140. [6]. SHI Peng,JIA Shuyu,ZHANG Xuxiang,et al.Metagenomic insights into chlorination effects on microbial antibiotic resistance in drinking water.[J].Water Research,2013,47(1):111-120. [7]. YANG Yuyi,LIU Wenzhi,XU Chen,et al.Antibiotic resistance genes in lakes from middle and lower reaches of the Yangtze River,China:Effect of land use and sediment characteristics[J].Chemosphere,2017,178:19-25. [8] Huang, K., Tang, J., Zhang, X. X., Xu, K., Ren, H. A comprehensive insight into tetracycline resistant bacteria and antibiotic resistance genes in activated sludge using next-generation sequencing. International Journal of Molecular Sciences, 2014, 15(6), 3368-3374. [9] Brooks, J. P., Adeli, A., McLaughlin, M. R. Microbial ecology, bacterial pathogens, and antibiotic resistant genes in swine manure wastewater as influenced by three swine management systems. Water Research, 2014, 57: 96-103. [10] Gao P., Munir M., Xagoraraki I. Correlation of tetracycline and sulfonamide antibiotics with corresponding resistance genes and resistant bacteria in a conventional municipal wastewater treatment plant. Science of the Total Environment, 2012, 421-422: 173-183. [11] Huang J. J., Hu H. Y., Wu Y. H., et al. Effect of chlorination and ultraviolet disinfection on tetA-mediated tetracycline resistance of Escherichia coli. Chemosphere, 2013, 90(8): 2247-2253. [12] Yuan Qingbin, Guo, Meiting, Yang Jian. Monitoring and assessing the impact of wastewater treatment on release of antibiotic-resistant bacteria and their typical genes in a Chinese municipal wastewater treatment plant Environ. Sci.: Processes Impacts, 2014, 16: 1930-1936.

3. 毕业设计（论文）进程安排

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