1. 毕业设计（论文）的内容和要求

酮酰酯化合物是广泛存在于具有生物活性化合物中的重要的结构单元。

由于它的重要生理活性已经引起化学家的广泛关注。

除此之外，酮酰酯类化合物还可作为中间体，进一步的转换合成许多其他功能性化合物。

2. 参考文献

1 (a) Y. Nie, R. Xiao, Y. Xu and G. T. Montelione, Org. Biomol.Chem., 2011, 9, 4070; (b) T. Kawasuji and T. Yoshinaga, PCT Int. Appl., WO 2001017968 A1 20010315, 2001; (c) Y. Aoki, S. Tanimoto, D. Takahashi and K. Toshima, Chem. Commun., 2013, 49, 1169; (d) I. Hemeon and A. J. Bennet, Synthesis, 2007, 1899. 2 (a) Y. Gravenfors, J. Viklund, J. Blid, T. Ginman, S. Karlstr#246;m, J. Kihlstr#246;m, K. Kolmodin, J. Lindstr#246;m, S. Berg, F. Kieseritzky, C. Slivo, B.-M. Swahn, L.-L. Olsson, P. Johansson, S. Eketj#228;ll, J. F#228;lting, F. Jeppsson, K. Str#246;mberg, J. Janson and F. Rahm, J. Med. Chem., 2012, 55, 9297; (b) B. A. Boughton, L. Hor, J. A. Gerrard and C. A. Hutton, Bioorg. Med. Chem., 2012, 20, 2419. 3 (a) A. De, V. Mauro, D. H. R. Barton, I. Bytheway, J. A. Ferreira, M. B. Hall, W. Liu, D. K. Taylor and L. Thomson, J. Am. Chem. Soc., 1995, 117, 4870; (b) A. Bacchi, M. Costa, C. N. Della, B. Gabriele, G. Salerno and S. Cassoni, J. Org. Chem., 2005, 70, 4971; (c) P. Wipf and C. R. J. Stephenson, Org. Lett., 2003, 5, 2449. 4 (a) V. Ozawa, N. Kawasaki, T. Yamamoto and A. Yamamoto, Chem. Lett., 1985, 567; (b) T. Sakakura, H. Yamashita, T. Kobayashi, T. Hayashi and M. Tanaka, J. Org. Chem., 1987, 52, 5733. 5 (a) S. R. Reddy, S. Stella and A. Chadha, Synth. Commun., 2012, 42, 3493; (b) R. Hosseinzadeh, M. Mohadjerani, M. Tajbakhsh and M. Nouzarian, Synth. Commun., 2011, 41, 1725; (c) E. V. Johnston, E. A. Karlsson, L.-H. Tran, B. Aakermark and J.-E. Baeckvall, Eur. J. Org. Chem., 2010, 1971. 6 (a) C. G. Screttas, B. R. Steele, M. Micha-Screttas and G. A. Heropoulos, Org. Lett., 2012, 14, 5680; (b) S. H. Kim, K. H. Kim and J. N. Kim, Adv. Synth. Catal., 2011, 353, 3335; (c) Y. Su, L. Zhang and N. Jiao, Org. Lett., 2011, 13, 2168; (d) M. Hayashi and S. Nakamura, Angew. Chem., Int. Ed., 2011, 50, 2249; (e) M. Lamani and K. R. Prabhu, Angew. Chem., Int. Ed., 2010, 49, 6622; (f) K. C. Nicolaou, Q. Kang, T. R. Wu, C. S. Lim and D. Y.-K. Chen, J. Am. Chem. Soc., 2010, 132, 7540. 7 (a) C.-J. Li, Acc. Chem. Res., 2009, 42, 335; (b) C. S. Yeung and V. M. Dong, Chem. Rev., 2011, 111, 1215; (c) Y. Zhang and C.-J. Li, J. Am. Chem. Soc., 2006, 128, 4242; (d) Z. Li and C.-J. Li, J. Am. Chem. Soc., 2006, 128, 56; (e) Y. Zhang and C.-J. Li, Angew. Chem., Int. Ed., 2006, 45, 1949; (f) Z. Li and C.-J. Li, J. Am. Chem. Soc., 2005, 127, 3672. 8 (a) A. E. Wendlandt, A. M. Suess and S. S. Stahl, Angew. Chem., Int. Ed., 2011, 50, 11062; (b) Z. Shi, C. Zhang, C. Tang and N. Jiao, Chem. Soc. Rev., 2012, 41, 3381; (c) C. Zhang, C. Tang and N. Jiao, Chem. Soc. Rev., 2012, 41, 3464; (d) A. N. Campbell and S. S. Stahl, Acc. Chem. Res., 2012, 45, 851. 9 C. Zhang, P. Feng and N. Jiao, J. Am. Chem. Soc., 2013, 135, 15257. 10 (a) C. B. Kelly, M. A. Mercadante, R. J. Wiles and N. E. Leadbeater, Org. Lett., 2013, 15, 2222; (b) X.-F. Wu, Tetrahedron Lett., 2012, 53, 3397; (c) J. Feng, S. Liang, S.-Y. Chen, J. Zhang, S.-S. Fu and X.-Q. Yu, Adv. Synth. Catal., 2012, 354, 1287; (d) K. Suzuki, T. Yamaguchi, K. Matsushita, C. Iitsuka, J. Miura, T. Akaogi and H. Ishida, ACS Catal., 2013, 3, 1845; (e) Y. Zhu and Y. Wei, RSC Adv., 2013, 3, 13668; (f) B. R. Travis, M. Sivakumar, G. O. Hollist and B. Borhan, Org. Lett., 2003, 5, 1031. (g) K. Ekoue-Kovi and C. Wolf, Chem.#8211;Eur. J., 2008, 14, 6302; (h) R. Samanta, K. Matcha and A. P. Antonchick, Eur. J. Org. Chem., 2013, 5769. 11 A.-K. C. Schmidt and C. B. W. Stark, Org. Lett., 2011, 13, 4164. 12 (a) C. Liu, J. Wang, L. Meng, Y. Deng, Y. Li and A. Lei, Angew. Chem., Int. Ed., 2011, 50, 5144; (b) S. Gowrisankar, H. Neumann and M. Beller, Angew. Chem., Int. Ed., 2011, 50, 5139. 13 C. Zhang, X. Zong, L. Zhang and N. Jiao, Org. Lett., 2012, 14, 3280. 14 C. Zhang and N. Jiao, Angew. Chem., Int. Ed., 2010, 49, 6174. 15 S. Murata, K. Suzuki, M. Miura and M. Nomura, J. Chem. Soc., Perkin Trans. 1, 1990, 361.

3. 毕业设计（论文）进程安排

起讫日期 设计（论文）各阶段工作内容 1.1-1.15 确定毕业设计的课题及相关资料的查找 2.22-3.10 实验方案的设计 3.10-3.20 实验材料的准备 3.21-5.10 工艺合成 5.10-6.5 实验数据处理与结果分析 5.20-6.10 毕业论文书写