1. 毕业设计（论文）的内容和要求

研究Alloferon对UVB伤害的小鼠皮肤组织的作用，通过转录组学分析，构建和细胞精细通路模型，根据pathway富集和PPI分析，结合蛋白质对接模拟计算，筛查靶点蛋白，揭示Alloferon的药物作用机制。

2. 参考文献

【1】Antiviral and antitumor peptides from insects. Sergey Chernysh, at al. PNAS, 2002. 【2】Activation of NF-jB by alloferon through down-regulation of antioxidant proteins and IkBa. Myung-Jeom Ryu, at al. Mol Cell Biochem, 2008. 【3】Inhibition of lytic reactivation of Kaposi#8217;s sarcoma- associated herpesvirus by alloferon. Wang Jae Lee, at al. Antiviral Therapy, 2011. 【4】Alloferon Alleviates Dextran Sulfate Sodium-induced Colitis. Hyemin Kim at al. Immune Network, 2015 【5】The anti-inflammatory effect of alloferon on UVB-induced skin inflammation through the down-regulation of pro-inflammatory cytokines. Wang Jae Lee at al. Immunology Letters, 2013 【6】Anti-inflammatory Effect of Alloferon on Ovalbumin-induced Asthma. Jae Seung Kang at al. Immune Network, 2015

3. 毕业设计（论文）进程安排

2月下旬-3月中旬：文献检索、实验准备、参加实验培训，准备样品 3月中旬--5月中旬：开展实验和数据分析。

5月中旬--六月上旬：论文写作、答辩。