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毕业论文网 > 任务书 > 化学化工与生命科学类 > 轻化工程 > 正文

聚谷氨酸基微纳米纤维排列方式与细胞粘附作用研究任务书

 2020-06-04 20:19:18  

1. 毕业设计(论文)的内容和要求

取向纤维结构使材料具有力学各向异性,提高纤维材料的取向
性,可以调控细胞运动功能。本课题主要以可降解聚谷氨酸为主要原料,聚氧化乙烯为辅助原料,制备微纳米纤维组织工程支架,通过控制纤维的排列方式研究其对细胞粘附及铺展性能的影响。

1. 具备高分子材料分子表征和纺丝液配制的能力 2. 掌握微纳米纤维表征和制备方法 3. 具备评价细胞相容性实验操作能力

2. 参考文献

[1] C.B. Frank, D.A. Hart, N.G. Shrive, Molecular biology and biomechanics of
normal and healing ligamentsa review, Osteoarthr. Cartil. 7 (1) (1999)
130e140.
[2] C. Frank, D. McDonald, D. Bray, R. Bray, R. Rangayyan, D. Chimich, N. Shrive,
Collagen fibril diameters in the healing adult rabbit medial collateral ligament,
Connect. Tissue Res. 27 (4) (1992) 251e263. PM:1576825.
[3] C. Frank, D. McDonald, N. Shrive, Collagen fibril diameters in the rabbit medial
collateral ligament scar: a longer term assessment, Connect. Tissue Res. 36 (3)
(1997) 261e269. PM:9512894.
[4] C.J. Doillon, M.G. Dunn, E. Bender, F.H. Silver, Collagen fiber formation in repair
tissue: development of strength and toughness, Coll. Relat. Res. 5 (6) (1985)
481e492. PM:3833451.
[5] T.W. Lin, L. Cardenas, L.J. Soslowsky, Biomechanics of tendon injury and repair,
J. Biomech. 37 (6) (2004) 865e877. PM:15111074.
[6] K.A. Hildebrand, C.B. Frank, Scar formation and ligament healing, Can. J. Surg.
41 (6) (1998) 425.
[7] J.A. Gimbel, J.P. Van Kleunen, S. Mehta, S.M. Perry, G.R. Williams,
L.J. Soslowsky, Supraspinatus tendon organizational and mechanical properties
in a chronic rotator cuff tear animal model, J. Biomech. 37 (5) (2004)
739e749. PM:15047003.
[8] K.L. Moffat, A.S. Kwei, J.P. Spalazzi, S.B. Doty, W.N. Levine, H.H. Lu, Novel
nanofiber-based scaffold for rotator cuff repair and augmentation, Tissue Eng.
Part A 15 (1) (2009) 115e126. PM:18788982.
[9] C.H. Lee, H.J. Shin, I.H. Cho, Y.M. Kang, I.A. Kim, K.D. Park, J.W. Shin, Nanofiber
alignment and direction of mechanical strain affect the ECM production of
human ACL fibroblast, Biomaterials 26 (11) (2005) 1261e1270. PM:15475056.
[10] J. Xie, X. Li, J. Lipner, C.N. Manning, A.G. Schwartz, S. Thomopoulos, Y. Xia,
”Aligned-to-random” nanofiber scaffolds for mimicking the structure of the
tendon-to-bone insertion site, Nanoscale 2 (6) (2010) 923e926.
[11] Z.X. Meng, Y.S. Wang, C. Ma, W. Zheng, L. Li, Y.F. Zheng, Electrospinning of
PLGA/gelatin randomly-oriented and aligned nanofibers as potential scaffold
in tissue engineering, Mater. Sci. Eng. C 30 (8) (2010) 1204e1210.

3. 毕业设计(论文)进程安排

1. 2016.12-2017.1 文献调研及路线设计; 2. 2017.2-2017.6 材料制备及性能表征优化; 3. 2017.6 数据整理及论文写作。

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